Expression of the helix-loop-helix gene id3 in the zebrafish embryo
Expression of the helix-loop-helix gene id3 in the zebrafish embryo
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DOI：
10.1016/s0925-4773(02)00006-0
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发表时间：
2002-04-01
影响因子：
2.6
通讯作者：
Strähle, U
中科院分区：
文献类型：
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作者：
Dickmeis, T;Rastegar, S;Strähle, U
Helix-Loop-Helix （HLH）蛋白的Extramacrochactae和Id亚家族蛋白是bHLH转录因子的负调控因子。我们从斑马鱼中克隆了一个编码id3亚家族成员的cDNA。高水平的转录本在胚环和胚盾中积累。在原肠胚形成末期，Id3在脊索前板和下母细胞高度表达。在后期，id3的表达在短时间内在多种组织中开启和关闭。其中包括外侧中胚层。角膜，晶状体，大脑，神经嵴，视网膜和鳍。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
Proteins of the Extramacrochactae and Id subfamily of Helix-Loop-Helix (HLH) proteins are negative regulators of bHLH transcription factors. We cloned a cDNA from zebrafish which encodes a member of the id3 subfamily. High levels of transcripts accumulated in the germ ring and in the embryonic shield. Towards the end of gastrulation, Id3 was highly expressed in the anterior prechordal plate and hypoblast. At later stages, id3 expression was turned on and off in a large variety of tissues within short periods of time. These include the lateral mesoderm. the cornea, the lens, the brain, the neural crest, the retina and the fins. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.