Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease.
Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease.
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DOI：
10.1002/jlb.1mr1117-442rr
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发表时间：
2018-07
影响因子：
5.5
通讯作者：
Berdnikovs S
中科院分区：
文献类型：
--
作者：
Abdala-Valencia H;Coden ME;Chiarella SE;Jacobsen EA;Bochner BS;Lee JJ;Berdnikovs S
嗜酸性粒细胞在不同组织中发挥稳态作用，并在稳态基线的几个器官中发现，尽管它们的组织数量在发育和疾病中显著增加。招募的嗜酸性粒细胞的形态、表型和功能可塑性受到稳态、形态发生和疾病状态之间的动态组织微环境变化的影响。上皮-间充质界面的活性、细胞外基质、激素输入、环境的代谢状态以及上皮和间充质衍生的先天性细胞因子和生长因子都具有调节嗜酸性粒细胞的吸引、保留、原位造血、表型和功能的潜力。本文综述了嗜酸性粒细胞和这些组织因子之间的相互关系，特别涉及：1）与嗜酸性粒细胞的存在和活动相关的组织微环境; 2）调节嗜酸性粒细胞积聚，造血，表型和功能的非免疫组织配体（重点是细胞外基质和上皮-间充质界面）; 3）嗜酸性粒细胞对调节组织生物学的贡献; 4）不同组织微环境中的嗜酸性粒细胞表型异质性，将嗜酸性粒细胞分类为祖细胞、稳态嗜酸性粒细胞以及1型和2型活化表型。非免疫组织因子对嗜酸性粒细胞调节的评价对于完成嗜酸性粒细胞免疫激活的图片和理解这些细胞对发育、稳态和疾病的功能贡献是必要的。
Eosinophils play homeostatic roles in different tissues and are found in several organs at a homeostatic baseline, though their tissue numbers increase significantly in development and disease. The morphological, phenotypical, and functional plasticity of recruited eosinophils are influenced by the dynamic tissue microenvironment changes between homeostatic, morphogenetic, and disease states. Activity of the epithelial-mesenchymal interface, extracellular matrix, hormonal inputs, metabolic state of the environment, as well as epithelial and mesenchymal-derived innate cytokines and growth factors all have the potential to regulate the attraction, retention, in situ hematopoiesis, phenotype, and function of eosinophils. This review examines the reciprocal relationship between eosinophils and such tissue factors, specifically addressing: 1) tissue microenvironments associated with the presence and activity of eosinophils; 2) non-immune tissue ligands regulatory for eosinophil accumulation, hematopoiesis, phenotype, and function (with an emphasis on the extracellular matrix and epithelial-mesenchymal interface); 3) the contribution of eosinophils to regulating tissue biology; 4) eosinophil phenotypic heterogeneity in different tissue microenvironments, classifying eosinophils as progenitors, steady state eosinophils, and Type 1 and 2 activated phenotypes. An appreciation of eosinophil regulation by non-immune tissue factors is necessary for completing the picture of eosinophil immune activation and understanding the functional contribution of these cells to development, homeostasis, and disease.