Phenotypic analysis of adhesion molecules in first-trimester decidual tissue from chorion villus samples.
Phenotypic analysis of adhesion molecules in first-trimester decidual tissue from chorion villus samples.
复制标题
绒毛膜绒毛样品中妊娠早期蜕膜组织中粘附分子的表型分析。
DOI：
10.1111/j.1600-0897.1997.tb00322.x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Smith,JB
中科院分区：
文献类型：
--
作者：
Haynes,MK;Wapner,RL;Jackson,LG;Smith,JB
PROBLEM: First‐trimester decidua contain CD56bright/CD16neglymphocytes that phenotypically resemble a subset of peripheral blood natural killer (NK) cells. Factors controlling their localization to decidua are unknown, but they may relate to trophoblast invasion, endometrial decidualization, and adhesion molecule expression.METHOD OF STUDY: Ninety‐one chorion villous samples (CVS) were screened for the presence of decidua, and selected specimens were analyzed for the expression of adhesion molecule pairs using a panel of monoclonal antibodies.RESULTS: Lymphoid cells in CVS‐derived decidua expressed CD56, PECAM, intracellular adhesion molecule‐1 (ICAM‐1), and the integrins LFA‐1, αEβ7, and α4β1, and co‐receptors for these molecules were expressed by decidual stromal cells, invasive trophoblasts, and venule endothelium. Some endothelium expressed a cuboidal phenotype.CONCLUSIONS: The expression of complimentary pairs of adhesion molecules by maternal lymphoid cells and by either extravillous cytotrophoblast or decidual stromal cells supports the hypothesis that these cells interact within decidua. Also, both LFA‐1 and α4β1 may contribute to decidual localization of CD56brightNK cells.
