New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP
New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP
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DOI：
10.1016/j.fitote.2018.03.012
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发表时间：
2018-06-01
期刊：
影响因子：
3.4
通讯作者：
Shiono, Yoshihito
中科院分区：
文献类型：
--
作者：
Ariefta, Nanang Rudianto;Kristiana, Priska;Shiono, Yoshihito
从拟毛丛赤壳菌（Nectria pseudotrichia）120- 1 NP的糙米培养物中分离得到四个新化合物，即三唑酮A（2）和B（3），三唑醌B（5），以及zythiostromic acid C（8），另外还有四个已知化合物（1，4，6，7）。据我们所知，这是第一次报告的4从自然来源。通过1D/2D-NMR谱和HRESITOFMS数据确定了它们的结构。此外，用改进的Mosher酯法测定了8个仲醇的绝对构型。对所有分离的化合物进行了抗菌活性、植物毒性和细胞毒性评价。
Four new compounds, namely, nectriapyrones A (2) and B (3), nectriaquinone B (5), and zythiostromic acid C (8), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP together with four known compounds (1, 4, 6, and 7). To the best of our knowledge, this is the first report of 4 from a natural source. Their structures were determined on the basis of 1D/2D-NMR spectroscopy and HRESITOFMS data. In addition, the absolute configuration of secondary alcohols in 8 were determined using modified Mosher's ester method. All isolated compounds were evaluated for their antimicrobials activity, phytotoxicity, and cytotoxicity.