Patient-specific in vivo right ventricle material parameter estimation for patients with tetralogy of Fallot using MRI-based models with different zero-load diastole and systole morphologies.
Patient-specific in vivo right ventricle material parameter estimation for patients with tetralogy of Fallot using MRI-based models with different zero-load diastole and systole morphologies.
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使用具有不同零负荷舒张期和收缩期形态的基于 MRI 的模型对法洛四联症患者进行患者特异性体内右心室材料参数估计
DOI：
10.1016/j.ijcard.2018.09.030
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发表时间：
2019-02-01
影响因子：
3.5
通讯作者：
Tang D
中科院分区：
文献类型：
--
作者：
Yu H;Del Nido PJ;Geva T;Yang C;Tang A;Wu Z;Rathod RH;Huang X;Billiar KL;Tang D
患者特异性体内心室材料参数的测定对心血管调查很重要。采用一种新的基于心脏磁成像（CMR）的建模方法，采用不同的零负荷舒张和收缩几何形状来估计健康人和法洛四联症（TOF）患者的右心室物质参数值，并寻求潜在的临床应用。CMR数据来自6名健康志愿者和16名获得同意的TOF患者。采用两种零负荷几何（舒张期和收缩期，2G模型）构建基于cmr的RV/LV模型。记录开始填充（BF），结束填充（EF），开始弹出（BE）和结束弹出（EE）的材料参数值进行分析。为了便于比较，计算了纤维方向应力应变曲线的有效杨氏模量（YM）。TOF患者的平均EE YM值比健康组（HG）高78.6%。预后较差的TOF组（WG）肺动脉瓣置换术（PVR）术后平均射血终末YM值比预后较好的TOF组（BG）高59.5%。采用开始填充YM和结束射血YM作为预测因子，采用经典logistic回归模型对不同预后较好组和较差组患者进行分析，发现开始填充YM和结束射血YM的受试者工作特征（ROC）曲线下面积分别为0.797和0.883。以终射YM为预测因子，敏感性0.761，特异性0.755。这项初步研究表明，心室材料刚度可能是区分BG患者和WG患者的一个潜在参数，需要进一步的努力和大规模的患者数据验证。
Patient-specific in vivo ventricle material parameter determination is important for cardiovascular investigations. A new cardiac magnetic image (CMR)-based modeling approach with different zero-load diastole and systole geometries was adopted to estimate right ventricle material parameter values for healthy and patients with Tetralogy of Fallot (TOF) and seeking potential clinical applications. CMR data were obtained from 6 healthy volunteers and 16 TOF patients with consent obtained. CMR-based RV/LV models were constructed using two zero-load geometries (diastole and systole, 2G model). Material parameter values for begin-filling (BF), end-filling (EF), begin-ejection (BE), and end-ejection (EE) were recorded for analyses. Effective Young’s moduli (YM) for fiber direction stress-strain curves were calculated for easy comparisons. The mean EE YM value of TOF patients was 78.6% higher than that of the healthy group (HG). The mean end-ejection YM value from worse-outcome TOF group (WG) post pulmonary valve replacement (PVR) surgery was 59.5% higher than that from the better-outcome TOF group (BG). Using begin-filling YM and end-ejection YM as predictors and the classic logistic regression model to different better-outcome group patients from worse-outcome group patients, the areas under Receiver Operating Characteristic (ROC) curves were found to be 0.797 and 0.883 for begin-filling YM and end-ejection YM, respectively. The sensitivity and specificity 0.761 and 0.755 using end-ejection YM as the predictor. This preliminary study suggests that ventricle material stiffness could be a potential parameter to be used to differentiate BG patients from WG patients with further effort and large-scale patient data validations.
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影响因子：
37.8
作者：
Geva T;Gauvreau K;Powell AJ;Cecchin F;Rhodes J;Geva J;del Nido P
通讯作者：
del Nido P
影响因子：
3.5
作者：
Asner, Liya;Hadjicharalambous, Myrianthi;Chabiniok, Radomir;Peresutti, Devis;Sammut, Eva;Wong, James;Carr-White, Gerald;Chowienczyk, Philip;Lee, Jack;King, Andrew;Smith, Nicolas;Razavi, Reza;Nordsletten, David
通讯作者：
Nordsletten, David
基于 MRI 的左心室应变和应变率分析：改进的分层变换模型
影响因子：
3.9
作者：
Gan Y;Chen Q;Zhang S;Ju S;Li ZY
通讯作者：
Li ZY
材料硬度参数作为左心室心肌梗塞存在的潜在预测因子：基于 3D 回波的计算建模研究
影响因子：
3.9
作者：
Fan L;Yao J;Yang C;Wu Z;Xu D;Tang D
通讯作者：
Tang D
DOI：
10.1115/1.2796031
发表时间：
1996-11-01
影响因子：
1.7
作者：
Costa, KD;Hunter, PJ;McCulloch, AD
通讯作者：
McCulloch, AD