Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19.
Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19.
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DOI：
10.1002/jmv.26720
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发表时间：
2021-04
影响因子：
12.7
通讯作者：
Hu W
中科院分区：
文献类型：
--
作者：
Bodnar B;Patel K;Ho W;Luo JJ;Hu W
SARS-CoV-2感染患者主要表现为呼吸道症状。然而，临床观察经常发现与 COVID-19（Neuro-SARS2）相关的神经系统症状和神经精神疾病。积累的有力证据表明，Neuro-SARS2可能在加剧疾病严重程度和死亡率方面发挥重要作用。了解 Neuro-SARS2 的神经发病机制和细胞机制对于基础研究和临床实践至关重要，以建立早期检测/诊断、预防和治疗范式的有效策略。在这篇综述中，我们将全面检查各种神经细胞中 SARS-CoV-2 感染的现有证据，包括神经元、小胶质细胞/巨噬细胞、星形胶质细胞、周细胞/内皮细胞、室管膜细胞/脉络膜上皮细胞和神经干/祖细胞。尽管在研究 Neuro-SARS2 方面已经取得了重大进展，但关于该病毒的神经侵袭途径（跨神经元和血源性）以及该疾病发生/进展的细胞/分子机制仍有待了解。未来和正在进行的研究需要使用人类诱导多能干细胞、脑类器官和死后标本建立更具临床相关性和合适的神经细胞模型。
Patients with SARS-CoV-2 infection manifest mainly respiratory symptoms. However, clinical observations frequently identified neurological symptoms and neuropsychiatric disorders related to COVID-19 (Neuro-SARS2). Accumulated robust evidence indicates that Neuro-SARS2 may play an important role in aggravating the disease severity and mortality. Understanding the neuropathogenesis and cellular mechanisms underlying Neuro-SARS2 is crucial for both basic research and clinical practice to establish effective strategies for early detection/diagnosis, prevention, and treatment paradigms. In this review, we will comprehensively examine current evidence of SARS-CoV-2 infection in various neural cells including neurons, microglia/macrophages, astrocytes, pericytes/endothelial cells, ependymocytes/choroid epithelial cells, and neural stem/progenitor cells. Although significant progress has been made in studying Neuro-SARS2, much remains to be learned about the neuroinvasive routes (transneuronal and hematogenous) of the virus and the cellular/molecular mechanisms underlying the development/progression of this disease. Future and ongoing studies require the establishment of more clinically relevant and suitable neural cell models using human induced pluripotent stem cells, brain organoids and postmortem specimens.
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影响因子：
13.6
作者：
通讯作者：
--
DOI：
10.1096/fj.202001808r
发表时间：
2020-12
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Alexander MR;Schoeder CT;Brown JA;Smart CD;Moth C;Wikswo JP;Capra JA;Meiler J;Chen W;Madhur MS
通讯作者：
Madhur MS
影响因子：
15.1
作者：
Bryche, Bertrand;St Albin, Audrey;Meunier, Nicolas
通讯作者：
Meunier, Nicolas
影响因子：
9.9
作者：
Benussi, Alberto;Pilotto, Andrea;Padovani, Alessandro
通讯作者：
Padovani, Alessandro
影响因子：
5
作者：
Bilinska, Katarzyna;Jakubowska, Patrycja;Butowt, Rafal
通讯作者：
Butowt, Rafal