Current Concepts of Neurodegenerative Mechanisms in Alzheimer's Disease.
Current Concepts of Neurodegenerative Mechanisms in Alzheimer's Disease.
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DOI：
10.1155/2018/3740461
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发表时间：
2018
影响因子：
--
通讯作者：
Haleagrahara N
中科院分区：
文献类型：
--
作者：
Magalingam KB;Radhakrishnan A;Ping NS;Haleagrahara N
神经退行性疾病是导致神经元结构和功能进行性丧失以及神经元死亡的遗传性或散发性病症。虽然一系列疾病都属于这一术语，但阿尔茨海默病（AD）和帕金森病（PD）是影响地球仪周围大量人口的最常见的神经退行性疾病。阿尔茨海默病的特征在于脑区域中细胞外淀粉样蛋白-β斑块和神经元内神经元缠结的异常积累，并且表现为老年个体中的一种痴呆，其导致记忆丧失、多种认知异常和智力残疾，干扰生活质量。自从发现AD以来，已经出现了大量的新信息，描述了疾病的原因、机制和潜在的治疗剂，但是尚未确定治愈这些疾病的有效疗法。这可能是因为疾病过程的复杂性，因为它涉及各种因素，包括环境因素和遗传倾向。本文综述了目前对导致AD病理学出现的神经退行性变机制的认识。
Neurodegenerative diseases are hereditary or sporadic conditions that result in the progressive loss of the structure and function of neurons as well as neuronal death. Although a range of diseases lie under this umbrella term, Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases that affect a large population around the globe. Alzheimer's disease is characterized by the abnormal accumulation of extracellular amyloid-β plaques and intraneuronal neurofibrillary tangles in brain regions and manifests as a type of dementia in aged individuals that results in memory loss, multiple cognitive abnormalities, and intellectual disabilities that interfere with quality of life. Since the discovery of AD, a wealth of new information has emerged that delineates the causes, mechanisms of disease, and potential therapeutic agents, but an effective remedy to cure the diseases has not been identified yet. This could be because of the complexity of the disease process, as it involves various contributing factors that include environmental factors and genetic predispositions. This review summarizes the current understanding on neurodegenerative mechanisms that lead to the emergence of the pathology of AD.
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影响因子：
3.7
作者：
Cha MY;Han SH;Son SM;Hong HS;Choi YJ;Byun J;Mook-Jung I
通讯作者：
Mook-Jung I
影响因子：
6.1
作者：
Combs B;Hamel C;Kanaan NM
通讯作者：
Kanaan NM
影响因子：
4.7
作者：
Caggiano, AO;Kraig, RP
通讯作者：
Kraig, RP
影响因子：
3.5
作者：
Fontan-Lozano, Angela;Romero-Granados, Rocio;Carrion, Angel M.
通讯作者：
Carrion, Angel M.
影响因子：
4.2
作者：
Amadoro, Giuseppina;Corsetti, Veronica;Calissano, Pietro
通讯作者：
Calissano, Pietro