ORIGINS AND COLLATERALIZATION OF CORTICOSPINAL, CORTICOPONTINE, CORTICORUBRAL AND CORTICOSTRIATAL TRACTS - A MULTIPLE RETROGRADE FLUORESCENT TRACING STUDY
ORIGINS AND COLLATERALIZATION OF CORTICOSPINAL, CORTICOPONTINE, CORTICORUBRAL AND CORTICOSTRIATAL TRACTS - A MULTIPLE RETROGRADE FLUORESCENT TRACING STUDY
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DOI：
10.1016/0006-8993(92)91629-s
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发表时间：
1992-07-24
期刊：
影响因子：
2.9
通讯作者：
BUXTON, DF
中科院分区：
文献类型：
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作者：
AKINTUNDE, A;BUXTON, DF
用碘化丙啶（PI）、固蓝（FB）、荧光金（FG）和二脒基黄（DY）同时逆行追踪大鼠皮质脊髓（CST）、皮质桥脑（CP）、皮质红核（CR）和皮质纹状体（CS）纤维的起源细胞。将PI注入对侧C4脊髓节段，FB、FG和DY分别注入同侧桥内侧核、红核和纹状体。标记的锥体神经元投射皮质脊髓轴突的对侧注射V层，大小从小到大不等。这些CST神经元占据两个不同的皮质区域。皮质桥脑、皮质红核和皮质纹状体纤维的皮质神经元起源于注射的同侧。标记的神经元位于皮质板V的皮质桥脑和皮质红核纤维，而皮质纹状体神经元位于板III，V和VI。CP、CR和CS标记的细胞占据一个大的皮质区域，该区域在地形上包括内侧（AGm）和外侧（AGl）无颗粒皮质和初级（SI）躯体感觉皮质的部分。相当大的重叠的皮质神经元的起源为四个运动纤维系统是显而易见的。超过98%的标记细胞是单标记的，而不到2%是双标记的。没有观察到三重或四重标记的神经元。因此，形态学证据表明，皮质运动神经元项目主要是个人，而不是侧支，轴突的四个运动相关的核在这项研究中的每一个。然而，只有少数皮质神经元同时投射轴突到最多两个参与运动通路的核。
Cerebral cells of origin for the corticospinal (CST), corticopontine (CP), corticorubral (CR) and corticostriatal (CS) fibers in the rat were identified following the simultaneous retrograde transport of propidium iodide (PI), fast blue (FB), fluorogold (FG) and diamidino yellow (DY). PI was injected into the contralateral C4 spinal cord segment while FB, FG and DY were injected into the ipsilateral medial pontine nuclei, red nucleus and striatum, respectively. Labeled pyramidal neurons projecting corticospinal axons were contralateral to injection in lamina V and ranged in size from small to large. These CST neurons occupied two distinct cortical areas. The cortical neurons of origin for the corticopontine, corticorubral and corticostriatal fibers were ipsilateral to injections. Labeled neurons were localized in cortical lamina V for the corticopontine and corticorubral fibers while corticostriate neurons were located in laminae III, V and VI. The CP, CR and CS labeled cells occupied one large cortical area which topographically included parts of the medial (AGm) and lateral (AGl) agranular cortices and the primary (SI) somatosensory cortex. Considerable overlapping of the cortical neurons of origin for the four motor fiber systems was apparent. More than 98% of the labeled cel[s were single labeled while less than 2% were double labeled. No triple or quadruple labeled neurons were observed. Hence, morphological evidence is presented that cortical motor neurons project mainly individual, rather than collateral, axons to each of the four motor associated nuclei investigated in this study. However, only a few cortical neurons projected axons simultaneously to a maximum of two nuclei involved in the motor pathways.