No Increased Risk of Colorectal Adenomas in Spouses of Patients with Colorectal Neoplasia.
No Increased Risk of Colorectal Adenomas in Spouses of Patients with Colorectal Neoplasia.
复制标题
结直肠肿瘤患者的配偶患结直肠腺瘤的风险不会增加。
DOI：
10.1016/j.cgh.2019.03.038
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Lebwohl,Benjamin
中科院分区：
文献类型：
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作者：
Krigel,Anna;Tatonetti,NicholasP;Neugut,AlfredI;Lebwohl,Benjamin
尽管家族史等遗传因素与罹患结直肠癌 (CRC) 的风险增加有关，但已确定了多种导致结直肠癌 (CRC) 的生活方式和环境风险因素，包括吸烟、饮食、肥胖和体力活动。1,2 尽管夫妻通常有不同的遗传背景，但配偶在多年来可能会分享生活方式和环境暴露，包括相似的家庭环境、居住地理位置、饮食暴露和吸烟暴露。3 因此，人们可能会预期患者配偶中的结直肠癌发病率会增加与CRC；然而，关于这一主题的研究结果不一致。3-6 通过使用大量接受过结肠镜检查的配偶，我们旨在确定结肠镜检查患有结直肠肿瘤 (CRN) 的配偶患结直肠腺瘤的风险是否增加。
Although genetic factors such as family history have been associated with increased risk of developing colorectal cancer (CRC), multiple lifestyle and environmental risk factors for CRC have been identified, including smoking, diet, obesity, and physical activity.1,2 Although couples typically have different genetic backgrounds, spouses are likely to share lifestyle and environmental exposures over the course of years, including similar home environments, geographical locations of residence, dietary exposures, and smoking exposures.3 As such, one might expect that an increased CRC incidence would be seen among spouses of patients with CRC; however, studies on this topic have inconsistent results.3–6 By using a large cohort of spouses who have undergone colonoscopy, we aimed to determine whether the risk of colorectal adenomas is increased among spouses of those with colorectal neoplasia (CRN) on colonoscopy.