Influence of repetitive transcranial magnetic stimulation on disease severity and oxidative stress markers in the cerebrospinal fluid of patients with spinocerebellar degeneration
Influence of repetitive transcranial magnetic stimulation on disease severity and oxidative stress markers in the cerebrospinal fluid of patients with spinocerebellar degeneration
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DOI：
10.1179/016164105x39897
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发表时间：
2005-04-01
影响因子：
1.9
通讯作者：
Hayabara, T
中科院分区：
文献类型：
--
作者：
Ihara, Y;Takata, H;Hayabara, T
对20例脊髓小脑变性（SCD）患者进行重复经颅磁刺激（rTMS）治疗8周前后的共济失调严重程度、小脑半球血流量（CHEF）、抗坏血酸自由基（AFR）、超氧化物歧化酶蛋白、超氧化物清除活性和脑脊液（CSF）中8-羟基脱氧鸟苷（8-OHdG）进行了比较。SCD患者的AFR、8-OHdG和超氧阴离子清除活性高于19名对照。在SCD患者中，AFR和共济失调严重程度在rTMS后下降，CHBF增加。由于SCD患者的共济失调严重程度与CHEF或超氧化物清除活性呈负相关，rTMS的治疗机制可能涉及降低氧化应激和增加CHEF。
Ataxia severity, cerebellar hemispheric blood flow (CHEF), ascorbate free radical (AFR), superoxide dismutase protein, superoxide scavenging activity, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in cerebrospinal fluid (CSF) were compared before and after an 8-week course of repetitive transcranial magnetic stimulation (rTMS) in 20 patients with spinocerebellar degenerations (SCD). SCD patients showed higher AFR, 8-OHdG, and superoxide scavenging activity than 19 controls. In SCD patients, AFR and ataxia severity declined, and CHBF increased after rTMS. As the SCD patients showed negative correlations between ataxia severity and CHEF or superoxide scavenging activity, the therapeutic mechanism of rTMS may involve decreased oxidative stress and increased CHEF.