Reduction of the formation of dental plaque and gingivitis in humans by crude mutanase.
Reduction of the formation of dental plaque and gingivitis in humans by crude mutanase.
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通过粗齿斑酶减少人类牙菌斑和牙龈炎的形成。
DOI：
10.1111/j.1600-0722.1978.tb00613.x
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
S. Poulsen
中科院分区：
文献类型：
--
作者：
J. Kelstrup;P. Holm‐Pedersen;S. Poulsen
在一项双盲交叉研究中，在20名受试者中评估了含有变聚糖酶（α-1，3葡聚糖葡聚糖水解酶）的哈茨木霉酶制剂对牙菌斑积累和组成以及牙龈炎发生率的影响。酶制剂在口香糖中施用。在为期1周的两个测试期之前，进行至少3周的洁治和清洁牙齿、口腔卫生指导和受控卫生。在测试期间，停止口腔卫生措施，而这些人每天咀嚼六片口香糖，一半使用含酶口香糖，另一半使用安慰剂口香糖。试验期相同，仅使用酶胶代替安慰剂，反之亦然。对菌斑和牙龈炎的评估显示，与安慰剂治疗期间相比，酶治疗期间累积的菌斑较少，牙龈炎较少，但邻间菌斑的细菌学研究并未显示可解释临床结果的差异。用酶制剂治疗引起一些局部副作用，但在任何人中均未检测到原发性皮肤刺激、迟发型超敏反应和抗酶IgE。
The effect of a Trichoderma harzianum enzyme preparation containing mutanase (alpha-1,3 glucan glucanohydrolase) on plaque accumulation and composition and on occurrence of gingivitis was assessed in 20 persons in a double-blind cross-over investigation. The enzyme preparation was administered in chewing gum. Two test periods of 1 week were preceded by scaling and cleansing of the teeth, oral hygiene instruction, and controlled hygiene for at least 3 weeks. Oral hygiene measures were discontinued during the test periods, while the persons chewed six pieces of chewing gum per day, one half using enzyme-containing gum, and the other half using placebo gum. The test periods were identical, only enzyme gum was used instead of placebo, or vice versa. Evaluations of plaque and gingivitis showed that less plaque had accumulated and less gingivitis developed during the enzyme than during the placebo period, but bacteriologic studies of interproximal plaque did not reveal differences that could explain the clinical findings. Treatment with the enzyme preparation caused some local side effects, but no primary skin irritation, delayed hypersensitivity, nor anti-enzyme IgE was detected in any of the persons.