Three-dimensional real-time in vivo magnetic particle imaging
Three-dimensional real-time in vivo magnetic particle imaging
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DOI：
10.1088/0031-9155/54/5/l01
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发表时间：
2009-03-07
影响因子：
3.5
通讯作者：
Borgert, J.
中科院分区：
文献类型：
--
作者：
Weizenecker, J.;Gleich, B.;Borgert, J.
磁粒子成像（MPI）是一种新的断层成像方法，具有快速三维动态成像的潜力。到目前为止，只有高示踪剂浓度的动态2D体模实验已被证明。在这封信中，第一次在体内三维实时MPI扫描，揭示了使用临床批准的浓度的市售MRI造影剂的跳动小鼠心脏的细节。在20.4 x 12 x 16.8 mm（3）的3D视野下实现了21.5 ms的时间分辨率，空间分辨率足以分辨所有心室。有了这些能力，MPI向医疗应用迈出了一大步。
Magnetic particle imaging (MPI) is a new tomographic imaging method potentially capable of rapid 3D dynamic imaging of magnetic tracer materials. Until now, only dynamic 2D phantom experiments with high tracer concentrations have been demonstrated. In this letter, first in vivo 3D real-time MPI scans are presented revealing details of a beating mouse heart using a clinically approved concentration of a commercially available MRI contrast agent. A temporal resolution of 21.5 ms is achieved at a 3D field of view of 20.4 x 12 x 16.8 mm(3) with a spatial resolution sufficient to resolve all heart chambers. With these abilities, MPI has taken a huge step toward medical application.