Barium exposure increases the risk of congenital heart defects occurrence in offspring
Barium exposure increases the risk of congenital heart defects occurrence in offspring
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DOI：
10.1080/15563650.2017.1343479
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发表时间：
2018-02
影响因子：
3.3
通讯作者：
N. Zhang;Zhen Liu;Xiao-Xian Tian;Ming Chen;Ying Deng;Yixiong Guo;Nana Li;P. Yu;Jiaxiang Yang;Jun Zhu
中科院分区：
文献类型：
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作者：
N. Zhang;Zhen Liu;Xiao-Xian Tian;Ming Chen;Ying Deng;Yixiong Guo;Nana Li;P. Yu;Jiaxiang Yang;Jun Zhu
摘要背景：一些研究调查了重金属暴露和先天性心脏病（CHD）之间的关联。然而，关于钡暴露与CHD发生之间关系的数据有限。本研究的目的是分析母亲钡暴露与后代冠心病风险之间的关系。材料与方法：我们对399例病例和490例对照进行了病例对照研究。测定孕妇头发及胎儿胎盘中钡的浓度。我们使用逻辑回归分析来探讨钡暴露与冠心病风险之间的关系。结果如下：Logistic回归分析显示，CHD组母亲头发中钡浓度中位数为4.180 ng/mg（校正比值比[aOR]，1.230; 95%置信区间[CI]，1.146-1.321; p < .001），显著高于对照组（2.740 ng/mg）。此外，CHD组胎儿胎盘组织中钡的中位浓度为0.617 ng/mg，而对照组为0.447 ng/mg（aOR，1.392; 95% CI，1.074-1.659; p = 0.003）。不同类型冠心病患者发钡浓度与对照组比较差异有统计学意义。这些差异见于间隔缺损（p <0.001）、圆锥动脉干缺损（p <0.001）、右心室流出道梗阻（p <0.001）、左心室流出道梗阻（p <0.001）和肺静脉回流异常（p = 0.010）。胎儿组织中钡浓度的显著差异仅见于间隔缺损病例（p = 0.010）。结论：母体钡暴露与子代CHD风险呈剂量依赖性相关。我们的研究结果表明，冠心病的某些亚型的发生与钡暴露有关。
Abstract Context: Several studies have investigated the association between heavy metal exposure and congenital heart defects (CHDs). However, there are limited data regarding the relationship between barium exposure and the occurrence of CHDs. The objective of this study was to analyze the association between barium exposure in mothers and the risk of CHD in offspring. Materials and methods: We developed a case-control study with 399 cases and 490 controls with normal live births in China. The concentrations of barium in hair of pregnant woman and fetal placenta were measured. We used a logistic regression analysis to explore the association between barium exposure and the risk of CHD. Results: Logistic regression analysis indicated that the median concentration of barium in maternal hair in the CHD group was 4.180 ng/mg (adjusted odds ratio [aOR], 1.230; 95% confidence interval [CI], 1.146–1.321; p < .001), which was significantly higher than that in the control group (2.740 ng/mg). Furthermore, the median concentration of barium in fetal placental tissue in the CHD group was 0.617 ng/mg, while that in the control group was 0.447 ng/mg (aOR, 1.392; 95% CI, 1.074–1.659; p = .003). Significant differences in the concentration of barium in hair were also found between the different CHD subtypes and the controls. These differences were found in cases with septal defects (p < .001), conotruncal defects (p < .001), right ventricular outflow track obstruction (p < .001), left ventricular outflow track obstruction (p < .001), and anomalous pulmonary venous return (p = .010). Significantly different barium concentrations in fetal tissue were only found in cases with septal defects (p = .010). Conclusions: Maternal barium exposure was dose-dependently related to the risk of CHD in the offspring. Our findings suggest that the occurrence of some subtypes of CHD is associated with barium exposure.