The MAP2/Tau family of microtubule-associated proteins.
The MAP2/Tau family of microtubule-associated proteins.
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MAP2/Tau 微管相关蛋白家族。
DOI：
10.1186/gb-2004-6-1-204
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发表时间：
2005
期刊：
影响因子：
12.3
通讯作者：
中科院分区：
文献类型：
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作者：
微管相关蛋白2/Tau家族的微管相关蛋白（MAP）包括脊椎动物蛋白MAP 2、MAP 4和Tau以及其他动物中的同源物。它们以其调节微管网络的微管稳定活性作用而闻名，但越来越多的证据表明其功能范围更广。调控微管介导的转运。Tau还与阿尔茨海默病和其他痴呆症有关。微管相关蛋白2/Tau家族的微管相关蛋白（MAP）包括脊椎动物蛋白MAP 2、MAP 4和Tau以及其他动物中的同源物。该家族的所有三个脊椎动物成员都有选择性剪接形式;所有亚型都有一个保守的含有微管结合重复序列的羧基末端结构域和一个大小不等的氨基末端投影结构域。MAP 2和Tau存在于神经元中，而MAP 4存在于许多其他组织中，但通常不存在于神经元中。该家族的成员以其微管稳定活性和调节神经元轴突和树突中微管网络的作用而闻名。与这种简单的传统观点相反，越来越多的证据表明，它具有更广泛的功能，例如与丝状肌动蛋白结合，招募信号蛋白，以及调节微管介导的运输。Tau还与阿尔茨海默病和其他痴呆症有关。MAP 2与微管和F-肌动蛋白相互作用的能力可能对神经形态发生过程至关重要，例如神经突起始，在此期间微管和F-肌动蛋白的网络以协调的方式重组。已经鉴定了调节MAP 2/Tau家族蛋白的微管稳定活性的各种上游激酶和相互作用蛋白。
Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. They are best known for their microtubule-stabilizing activity roles regulating microtubule networks but, accumulating evidence suggests a much broader range of functions. regulation of microtubule-mediated transport. Tau is also implicated in Alzheimer’s disease and other dementias. Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. All three vertebrate members of the family have alternative splice forms; all isoforms share a conserved carboxy-terminal domain containing microtubule-binding repeats, and an amino-terminal projection domain of varying size. MAP2 and Tau are found in neurons, whereas MAP4 is present in many other tissues but is generally absent from neurons. Members of the family are best known for their microtubule-stabilizing activity and for proposed roles regulating microtubule networks in the axons and dendrites of neurons. Contrary to this simple, traditional view, accumulating evidence suggests a much broader range of functions, such as binding to filamentous (F) actin, recruitment of signaling proteins, and regulation of microtubule-mediated transport. Tau is also implicated in Alzheimer's disease and other dementias. The ability of MAP2 to interact with both microtubules and F-actin might be critical for neuromorphogenic processes, such as neurite initiation, during which networks of microtubules and F-actin are reorganized in a coordinated manner. Various upstream kinases and interacting proteins have been identified that regulate the microtubule-stabilizing activity of MAP2/Tau family proteins.