EFFECT OF AGING ON PLASMA-RENIN AND ALDOSTERONE IN NORMAL MAN
EFFECT OF AGING ON PLASMA-RENIN AND ALDOSTERONE IN NORMAL MAN
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DOI：
10.1038/ki.1975.120
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发表时间：
1975-01-01
影响因子：
19.6
通讯作者：
LIMA, JD
中科院分区：
文献类型：
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作者：
WEIDMANN, P;DEMYTTENAEREBURSZTEIN, S;LIMA, JD
衰老对正常人血浆肾素和醛固酮的影响：通过比较年轻（20~30岁）和老年（62~70岁）健康受试者，评价衰老对肾素-血管紧张素-醛固酮系统的影响。尽管两个年龄组的身体钠液平衡相当，但老年人的血清肾素浓度、血浆肾素活性和醛固酮浓度均较低。当受试者仰卧并接受正常钠摄入量时，与年龄相关的循环血浆中的血浆中的血管紧张素和醛固酮浓度下降幅度很小;当受试者直立时和钠消耗期间，这种下降更加明显。在正常钠摄入或轻度钠缺乏的四种研究条件中的两种条件下（分别为r =-0.44和-0.47），但在进行性钠缺乏期间，未观察到反向肾素-血压相关性。老年人血浆肾素水平降低，无论是否与血压呈负相关。老年人对促肾上腺皮质激素输注的醛固酮和皮质醇反应不变。得出的结论是，衰老可能会导致循环中的肾素减少，同时血浆醛固酮浓度也会降低。
Effect of aging on plasma renin and aldosterone in normal man. The influence of aging on the renin-angiotensin-aldosterone system was evaluated by comparing young (20 to 30 yr) with elderly (62 to 70 yr) healthy subjects. Despite comparable body sodium-fluid balance in the two age groups, serum renin concentration, plasma renin activity and aldosterone concentrations were lower in the elderly. The age-related decreases in circulating renin and aldosterone concentrations were slight while subjects were supine and receiving normal sodium intake; when upright and during sodium depletion, they were more pronounced. Inverse renin-blood pressure interrelations were noted during two of four study conditions involving normal sodium intake or mild sodium depletion (r = -0.44 and -0.47, respectively), but not during progressive sodium depletion. Plasma renin levels were decreased in the elderly regardless of the presence or absence of an inverse relationship with blood pressure. Aldosterone and Cortisol responses to corticotropin infusion were unaltered in the elderly. It is concluded that aging may cause a decrease in circulating renin, with parallel lowering of plasma aldosterone concentrations.