Effects of wide band inhibitors in the dorsal cochlear nucleus. II. Model calculations of the responses to complex sounds.
Effects of wide band inhibitors in the dorsal cochlear nucleus. II. Model calculations of the responses to complex sounds.
复制标题
宽带抑制剂对耳蜗背核的影响。
DOI：
10.1121/1.421349
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
M. Reed
中科院分区：
文献类型：
--
作者：
J. Blum;M. Reed
在耳蜗背核中的信号处理的先前建模研究中[Reed和Blum，J. Acoust. Soc. Am 96，1442-1453（1997）]，表明包含宽带抑制剂（WBI）极大地改善了IV型单元对纯音的模型响应图和实验响应图之间的拟合。在这项研究中，我们研究的影响WBI对复杂的声音刺激，如宽带噪声（BBN），陷波噪声，噪声频带，带/陷波组合的反应。一个新的和更现实的模型，在不同程度的噪声存在下的听觉神经（AN）的反应。它表明，人们可以解释和理解的定性特征，几乎所有的公布的数据类型II和IV型单位响应BBN，陷波噪声和噪声频带。在模型中，由于WBI对II型细胞的抑制作用增加，II型细胞的最大放电率对实验观察到的增加宽度的噪声带的单调递减响应发生。类似地，各种非单调模式的最大放电率的IV型单位的噪声频带的宽度增加所示，从复杂的和高度非线性的影响，抑制从II型到IV型和WBI到IV型细胞和非线性的直接激发从AN到IV型细胞。一些实验使用双缺口，双噪声带，或缺口噪声带对建议，通过与模型结果的比较，将允许一个推断可能的连接模式之间的类型II和类型IV的单位和WBI单位和类型IV的单位。
In a previous modeling study of signal processing in the dorsal cochlear nucleus [Reed and Blum, J. Acoust. Soc. Am 96, 1442-1453 (1997)] it was shown that inclusion of a wideband inhibitor (WBI) greatly improved the fit between model response maps and the experimental response maps of type IV units to pure tones. In this study we examine the effect of the WBI on the responses to complex sound stimuli such as broadband noise (BBN), notch noise, noise bands, and band/notch combinations. A new and more realistic model for auditory nerve (AN) response in the presence of different levels of noise is used. It is shown that one can explain and understand the qualitative features of virtually all the published data on type II and type IV unit responses to BBN, notch noise and noise bands. The monotone decreasing response of the maximum firing rate of type II units to noise bands of increasing width that is observed experimentally occurs in the model due to the increasing inhibition of type II cells by the WBI. Similarly, the various nonmonotone patterns of maximum firing rate of type IV units to noise bands of increasing width is shown to arise from the complex and highly nonlinear effects of inhibition from the type II to type IV and the WBI to type IV cells and the nonlinear direct excitation from the AN to the type IV cells. A number of experiments using double notches, double noise bands, or notch-noise band pairs are suggested which, by comparison with model results, would allow one to infer probable connectional patterns between type II and type IV units and between the WBI units and the type IV units.
影响因子：
2.5
作者：
COSTALUPES, JA;YOUNG, ED;GIBSON, DJ
通讯作者：
GIBSON, DJ