Simple and highly convenient two-step practical procedure for the synthesis of optically pure methyl D-erythro-2,3-dihydroxybutanoate
Simple and highly convenient two-step practical procedure for the synthesis of optically pure methyl D-erythro-2,3-dihydroxybutanoate
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DOI：
10.1002/adsc.200404353
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发表时间：
2005-04-01
影响因子：
5.4
通讯作者：
Aidhen, IS
中科院分区：
文献类型：
--
作者：
Mahalingam, SM;Sathyamurthi, N;Aidhen, IS
以d -红内酯为原料，用两个简单连续的反应合成了对映纯甲基d -红-2,3-二羟基丁酸。这两个反应是内酯与氢溴酸在甲醇中开环和随后的还原脱溴反应。
A synthesis of enantiopure methyl D-erythro-2,3-dihydroxybutanoate has been realized using two simple and consecutive reactions on D-erythronolactone as the starting material. The two reactions are lactone ring opening with hydrobromic acid in methanol and subsequent reductive debromination.