LUNG-CANCER CLASSIFICATION - THE RELATIONSHIP OF DISEASE EXTENT AND CELL TYPE TO SURVIVAL IN A CLINICAL-TRIALS POPULATION
LUNG-CANCER CLASSIFICATION - THE RELATIONSHIP OF DISEASE EXTENT AND CELL TYPE TO SURVIVAL IN A CLINICAL-TRIALS POPULATION
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DOI：
10.1002/jso.2930350302
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发表时间：
1987-07-01
影响因子：
2.5
通讯作者：
WEILAND, LH
中科院分区：
文献类型：
--
作者：
MOUNTAIN, CF;LUKEMAN, JM;WEILAND, LH
肺癌研究组（LCSG）临床试验项目中患者的分期和组织学细胞类型在肺癌解剖和病理分类参考中心进行审查和确认或解决。通过使用尽量减少观察者内部变异的标准，实现了分类的高度一致性。从审查项目中获得的数据已用于描述临床试验人群中疾病程度和细胞类型与生存的关系。1121例患者接受了非小细胞肺癌的明显完全切除，并随后进入各种方案，接受辅助治疗或不接受进一步治疗，获得了生存特征。最终结果研究提供了一些关于肺鳞癌和腺癌在明显完全切除时疾病解剖范围的生物学行为的见解。在每个TNM亚群中，鳞状细胞癌患者的预后优于腺癌患者。总体而言，这些主要细胞类型的生存差异在T1 NO、T1 N1和T2 N1亚群中是显著的，但在III期疾病的TNM亚群中没有差异。组织学细胞类型和疾病程度是影响生存预期的重要因素；因此，这些分类的准确性和可重复性在不同治疗方式的评估中起着重要作用。
The staging and histologic cell type of patients in the Lung Cancer Study Group (LCSG) clinical trials program are reviewed and confirmed or resolved at the reference center for anatomic and pathologic classification of lung cancer. A high level of consistency in classification has been achieved through the use of criteria that minimize intraobserver variability. The data obtained from the review project have been used to characterize the relationship of disease extent and cell type to survival in the clinical trials population. Survival characteristics were generated for 1,121 patients who underwent apparent complete resection of nonsmall cell lung cancer and were subsequently entered into various protocols to receive either adjuvant treatment or no further therapy. The end results study provides some insight regarding the biological behavior of squamous cell carcinoma and adenocarcinoma of the lung in terms of the anatomic extent of disease at the time of apparent complete resection. Patients with squamous cell carcinoma had an outcome superior to that of patients with adenocarcinoma in every TNM subset. The differences in survival according to these major cell types were significant overall and in the T1 NO, T1 N1, and T2 N1 subsets but not in the TNM subsets in stage III disease. Histologic cell type and extent of disease are important factors in survival expectations; thus the accuracy and reproducibility of these classifications plays a significant role in the evaluation of differing modalities of treatment.