Association between the coexistence of premorbid sarcopenia, frailty, and disability and functional outcome in older patients with acute stroke
Association between the coexistence of premorbid sarcopenia, frailty, and disability and functional outcome in older patients with acute stroke
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DOI：
10.1111/ggi.14432
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发表时间：
2022-07-18
影响因子：
3.3
通讯作者：
Shimada, Shinichi
中科院分区：
文献类型：
--
作者：
Nozoe, Masafumi;Noguchi, Madoka;Shimada, Shinichi
目的探讨老年急性卒中患者并发疾病如病前骨质疏松症、虚弱和残疾等对功能结局的影响。方法这项前瞻性队列研究包括在一家神经外科医院因急性中风住院的老年患者(年龄65岁)。采用SARC-F问卷、虚弱指数和入院时的改良Rankin量表(MRS)对发病前的骨质疏松症、虚弱和残疾进行诊断。主要结果是卒中后3个月的MRS评分，较差的结果被定义为MRS和GT；=4。结果这项研究包括317名老年急性卒中患者(中位数[四分位数范围]：76[12]岁)。分别有59例(19%)、27例(9%)和54例(17%)患者出现病前骨质疏松症、虚弱和残疾(MRS=2或3)。两种情况共存26例(8%)，三种情况共存18例(6%)。校正Logistic回归分析显示，合并条件与不良预后独立相关(1个条件，调整后OR：3.20[95%CI：0.98~10.45]；2个条件，调整后OR：6.57[95%CI：1.74~24.87]；3个条件，调整后OR：12.70[95%CI：2.65~60.91])。结论病前骨质疏松症、虚弱和残疾并存与老年急性卒中患者的功能预后不良有关。Geriatr Gerontol Int 2022；中心点中心点：中心点-中心点中心点。
Aim To investigate the effects of coexisting conditions such as premorbid sarcopenia, frailty, and disability on functional outcomes in older patients with acute stroke. Methods This prospective cohort study included older patients (aged >= 65 years) hospitalized for acute stroke at a single neurosurgical hospital. Premorbid sarcopenia, frailty, and disability were diagnosed using the strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire, frailty index, and modified Rankin Scale (mRS) on admission. The primary outcome was the mRS score 3 months after stroke, and a poor outcome was defined as mRS >= 4. Results This study included 317 older patients with acute stroke (median [interquartile range] age: 76 [12] years). Premorbid sarcopenia, frailty, and disability (mRS = 2 or 3) were identified in 59 (19%), 27 (9%), and 54 (17%) patients, respectively. Two coexisting conditions were observed in 26 patients (8%), and three were observed in 18 patients (6%). Adjusted logistic regression analysis revealed that coexisting conditions were independently associated with poor outcomes (one condition, adjusted OR: 3.20 [95%CI: 0.98-10.45]; two conditions, adjusted OR: 6.57 [95%CI: 1.74-24.87]; three conditions, adjusted OR: 12.70 [95%CI: 2.65-60.91]). Conclusions The coexistence of premorbid sarcopenia, frailty, and disability was associated with poor functional outcomes in older patients with acute stroke. Geriatr Gerontol Int 2022; center dot center dot: center dot center dot-center dot center dot.