Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment
Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment
复制标题
DOI：
10.3390/coatings9090561
复制
发表时间：
2019-09
期刊：
影响因子：
3.4
通讯作者：
S. Yamaguchi;Phuc Thi Minh Le;Morihiro Ito;Seine A. Shintani;H. Takadama
中科院分区：
文献类型：
--
作者：
S. Yamaguchi;Phuc Thi Minh Le;Morihiro Ito;Seine A. Shintani;H. Takadama
骨科和牙科钛（Ti）植入物的主要问题是骨与金属的结合不良。各种涂层，以改善骨结合，包括羟基磷灰石和二氧化钛，已经开发出来，其中一些已成功地应用于临床使用。另一方面，在钛上提供抗菌活性和促进骨生长仍然存在挑战。结果表明，钛及其合金上的缺钙钛酸钙涂层由于其磷灰石的形成而表现出高的骨结合。在这项研究中，Sr和Ag离子，已知其促进骨生长和抗菌活性，被引入到钙缺乏钛酸钙的三步水溶液处理结合热。经过处理的金属在模拟体液中3天内形成磷灰石，并对大肠杆菌表现出抗菌活性，而对MC 3 T3-E1前成骨细胞没有表现出任何细胞毒性。此外，金属缓慢释放1.29 ppm的Sr离子。具有掺杂有Sr和Ag的缺钙钛酸钙的Ti将可用于整形外科和牙科植入物，因为其由于其磷灰石形成而应当结合到骨，由于Sr离子释放而促进骨生长，并且由于其抗菌活性而防止感染。
The main problem of orthopedic and dental titanium (Ti) implants has been poor bone-bonding to the metal. Various coatings to improve the bone-bonding, including the hydroxyapatite and titania, have been developed, and some of them have been to successfully applied clinical use. On the other hand, there are still challenges to provide antibacterial activity and promotion of bone growth on Ti. It was shown that a calcium-deficient calcium titanate coating on Ti and its alloys exhibits high bone-bonding owing to its apatite formation. In this study, Sr and Ag ions, known for their promotion of bone growth and antibacterial activity, were introduced into the calcium-deficient calcium titanate by a three-step aqueous solution treatment combined with heat. The treated metal formed apatite within 3 days in a simulated body fluid and exhibited antibacterial activity to Escherichia coli without showing any cytotoxicity in MC3T3-E1 preosteoblast cells. Furthermore, the metal slowly released 1.29 ppm of Sr ions. The Ti with calcium-deficient calcium titanate doped with Sr and Ag will be useful for orthopedic and dental implants, since it should bond to bone because of its apatite formation, promote bone growth due to Sr ion release, and prevent infection owing to its antibacterial activity.