Lgr proteins in epithelial stem cell biology
Lgr proteins in epithelial stem cell biology
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DOI：
10.1242/dev.083113
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发表时间：
2013-06-15
期刊：
影响因子：
4.6
通讯作者：
Clevers, Hans
中科院分区：
文献类型：
--
作者：
Barker, Nick;Tan, Shawna;Clevers, Hans
利用成体干细胞用于再生医学的全球努力的最终成功将在很大程度上取决于强大的，高度选择性的干细胞表面标记物的可用性，这些标记物有助于从人体组织中分离干细胞。分离的干细胞的任何后续扩增或操作也将需要对调节这些细胞的机制的深入了解，以确保维持其再生能力，并最大限度地减少引入可能对患者造成健康风险的不良生长性状的风险。富含亮氨酸重复序列的G蛋白偶联受体（Lgr）蛋白的一个亚类最近作为成体干细胞标志物在维持干细胞功能方面发挥着至关重要的作用。在这里，我们讨论了他们的发现对我们理解各种自我更新组织中的成体干细胞生物学和加速有效干细胞疗法开发的重大影响。
The ultimate success of global efforts to exploit adult stem cells for regenerative medicine will depend heavily on the availability of robust, highly selective stem cell surface markers that facilitate the isolation of stem cells from human tissues. Any subsequent expansion or manipulation of isolated stem cells will also require an intimate knowledge of the mechanisms that regulate these cells, to ensure maintenance of their regenerative capacities and to minimize the risk of introducing undesirable growth traits that could pose health risks for patients. A subclass of leucine-rich repeat-containing G-protein-coupled receptor (Lgr) proteins has recently gained prominence as adult stem cell markers with crucial roles in maintaining stem cell functions. Here, we discuss the major impact that their discovery has had on our understanding of adult stem cell biology in various self-renewing tissues and in accelerating progress towards the development of effective stem cell therapies.