The ancient cytokine IL-17D is regulated by Nrf2 and mediates tumor and virus surveillance.
The ancient cytokine IL-17D is regulated by Nrf2 and mediates tumor and virus surveillance.
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古老的细胞因子 IL-17D 受 Nrf2 调节并介导肿瘤和病毒监测。
DOI：
10.1016/j.cyto.2016.11.017
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发表时间：
2017
期刊：
影响因子：
3.8
通讯作者：
Bui,JackD
中科院分区：
文献类型：
--
作者：
Seelige,Ruth;WashingtonJr,Allen;Bui,JackD
早期免疫反应可以决定炎症过程的严重程度和结果，如肿瘤生长和病毒感染。细胞因子如白细胞介素17（IL-17）家族和细胞应激防御（例如，抗氧化剂）途径很早就已经进化出来，并在脊椎动物和无脊椎动物中调节疾病监测，早在秀丽隐杆线虫（Caelophabditiselegans）时期。我们的小组最近发现了核因子红细胞衍生的2-like 2（Nrf 2）通过诱导IL-17 D和招募自然杀伤（NK）细胞来调节早期抗癌免疫反应的新作用。在这篇《细胞因子刺激》中，我们讨论了最近的研究结果，这些研究结果鼓励提高Nrf 2/IL-17 D/NK细胞轴用于治疗癌症和病毒感染。
Early stage immune responses can dictate the severity and outcome of inflammatory processes such as tumor growth and viral infection. Cytokines such as the interleukin 17 (IL-17) family and cellular stress defense (e.g., anti-oxidant) pathways have evolved early and regulate disease surveillance in vertebrates and invertebrates as far back as Caenorhabditis elegans. Our group has recently found a new role for nuclear factor erythroid-derived 2-like 2 (Nrf2) in regulating early anti-cancer immune responses by inducing IL-17D and recruiting natural killer (NK) cells. In thisCytokine Stimulus, we discuss recent findings that encourage boosting the Nrf2/IL-17D/NK cell axis for the treatment of cancer and viral infection.