Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects
Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects
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DOI：
10.1016/j.brs.2018.06.005
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发表时间：
2018-09-01
影响因子：
7.7
通讯作者：
Hoy, Kate E.
中科院分区：
文献类型：
--
作者：
Hill, Aron T.;Rogasch, Nigel C.;Hoy, Kate E.
背景：以前的研究通常集中在对单个皮层区域施加直流电的神经调节作用上。然而，复杂的过程，如工作记忆（WM），强烈依赖于更广泛的神经网络的激活，因此可能受益于对多个皮层靶点的刺激。目的：我们研究了高清晰度经颅直流电刺激（HD-tDCS）蒙太奇的神经生物学和认知效应，这些蒙太奇要么单独针对背外侧前额叶皮层（DLPFC），方法：16名健康受试者采用受试者内设计，分别接受DLPFC、DLPFC + PC和假刺激，并接受HD-tDCS。皮质反应性的变化进行了检查，使用经颅磁刺激结合脑电图（TMS-EEG），而振荡功率通过记录在n-back任务的EEG测量。WM性能也在几个单独的tasks.Results：刺激使用DLPFC或DLPFC + PC蒙太奇调制皮层反应，作为指数的P60 TMS诱发电位的增强。然而，相对于基线，仅双部位DLPFC棘PC刺激导致N100分量的振幅降低。与基线相比，在该导联组合后也观察到θ和γ功率增加，但在HD-tDCS后与单独DLPFC相比不存在。尽管这些神经生理变化，WM性能没有显着调制HD-tDCS，无论刺激montage.Conclusion：这些结果提供了重要的初步了解的行为和生物学效应的刺激在关键的皮层区域连接到WM和证明的灵敏度TMS-EEG和EEG在检测微妙的神经生理变化引起的HD-tDCS。(c)2018爱思唯尔公司All rights reserved.
Background: Previous research has typically focussed on the neuromodulatory effects of direct currents applied over single regions of the cortex. However, complex processes such as working memory (WM) strongly rely on activations across a wider neural network and therefore might benefit from stimulation administered over multiple cortical targets.Objective: We examined the neurobiological and cognitive effects of High-Definition transcranial direct current stimulation (HD-tDCS) montages that either targeted the dorsolateral prefrontal cortex (DLPFC) alone, or simultaneously stimulated the DLPFC and parietal cortex (DLPFC + PC).Methods: In a within-subjects design, 16 healthy participants completed three experimental sessions in which they received HD-tDCS over either the DLPFC, the DLPFC + PC or sham stimulation. Changes in cortical reactivity were examined using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG), while oscillatory power was measured via EEG recorded during n-back tasks. WM performance was also examined across several separate tasks.Results: Stimulation using both the DLPFC or DLPFC + PC montages modulated cortical reactivity, as indexed by potentiation of the P60 TMS-evoked potential. However, only the dual-site DLPFC thorn PC stimulation produced a reduction in the amplitude of the N100 component, relative to baseline. Increases in theta and gamma power were also observed following this montage, when compared to baseline, but were not present following HD-tDCS over the DLPFC alone. Despite these neurophysiological changes, WM performance was not significantly modulated by HD-tDCS, regardless of stimulation montage.Conclusion: These results provide important initial insight into the behavioural and biological effects of stimulation over key cortical regions linked to WM and attest to the sensitivity of TMS-EEG and EEG in detecting subtle neurophysiological changes induced by HD-tDCS. (c) 2018 Elsevier Inc. All rights reserved.