Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development
Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development
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DOI：
10.1016/s0925-4773(97)00044-0
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发表时间：
1997-06-01
影响因子：
2.6
通讯作者：
Arnold, HH
中科院分区：
文献类型：
--
作者：
Brand, T;Andree, B;Arnold, HH
cNkx2-8 代表转录因子 NK2 家族的新成员。该基因包含三个高度保守的区域：TN-、NK2- 和同源域，这些区域可诊断这组蛋白质。 cNkx2-8 在鸡胚胎发生期间在腹侧前肠内胚层、心肌中胚层、鳃弓上皮和背侧心中膜中表达。虽然 cNkx2-8 的表达与其他 NK 基因（例如 Nkx2-5 和 Nkx2-3）部分重叠，但其表达域的起始和方面是特定的。因此，结构数据和表达谱表明cNkx2-8构成了一种新的同源框蛋白，其可能与其已知的相关蛋白合作定义包括发育中的心脏和咽内胚层的前腹侧区域。 (C) 1997 爱思唯尔科学爱尔兰有限公司
cNkx2-8 represents a novel member of the NK2-family of transcription factors. The gene contains three highly conserved regions, the TN-, NK2-, and homeodomains which are diagnostic for this group of proteins. cNkx2-8 is expressed during chick embryogenesis in ventral foregut endoderm, myocardial mesoderm, epithelium of the branchial arches and the dorsal mesocardium. While cNkx2-8 expression partially overlaps with other NK genes, such as Nkx2-5 and Nkx2-3, its onset and aspects of its expression domains are specific. Thus, structural data and the expression profile suggest that cNkx2-8 constitutes a new homeobox protein which may cooperate with its known relatives in defining an antero-ventral field including the developing heart and pharyngeal endoderm. (C) 1997 Elsevier Science Ireland Ltd.