[Horizontal transfer of antibiotic resistance genes in the environment].
[Horizontal transfer of antibiotic resistance genes in the environment].
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发表时间：
2013-10
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影响因子：
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通讯作者：
Fenghua Yang;Daqing Mao;Yi Luo;Qing Wang;Quangui Mu
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文献类型：
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作者：
Fenghua Yang;Daqing Mao;Yi Luo;Qing Wang;Quangui Mu
抗生素耐药基因（antibiotic resistance genes, ARGs）是一种新型的环境污染物，其转移对环境的不良影响可能比ARGs本身更大，而水平基因转移（horizontal gene transfer， HGT）可能是ARGs最重要的传播途径，是ARGs污染日益严重的原因之一。本文系统阐述了水射流水平转移的分子机制及其影响因素，对研究水射流水平转移的分子机制具有重要意义。结合多种抗生素耐药的系统发育机制，提出了减少ARGs在环境中的转移和增殖的有效策略。基于目前的污染状况，展望了ARGs在环境中水平转移的进一步研究。
The transfer of antibiotic resistance genes (ARGs), a new type of environmental pollutants, could have more adverse effects on the environment than the ARGs themselves, while the horizontal gene transfer (HGT) could be the most important propagation pathways of the ARGs, being one of the reasons for the growing pollution of ARGs in the environment. This paper systematically elaborated the molecular elements of the horizontal transfer of ARGs and the related affecting factors, which was of significance for investigating the molecular mechanisms of the horizontal transfer of the ARGs. In combining with the phylogenetic mechanisms of multiple antibiotic resistances, this paper also provided effective strategies to reduce the transfer and proliferation of ARGs in the environment. Based on the present contamination situations, the further researches on the horizontal transfer of ARGs in the environment were prospected.