Peripheral arterial disease, type 2 diabetes and postprandial lipidaemia: Is there a link?
Peripheral arterial disease, type 2 diabetes and postprandial lipidaemia: Is there a link?
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DOI：
10.4239/wjd.v5.i5.577
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发表时间：
2014-10
影响因子：
4.2
通讯作者：
P. Valdivielso;José Ramírez-Bollero;Carmen Pérez-López
中科院分区：
文献类型：
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作者：
P. Valdivielso;José Ramírez-Bollero;Carmen Pérez-López
Peripheral arterial disease, manifested as intermittent claudication or critical ischaemia, or identified by an ankle/brachial index < 0.9, is present in at least one in every four patients with type 2 diabetes mellitus. Several reasons exist for peripheral arterial disease in diabetes. In addition to hyperglycaemia, smoking and hypertension, the dyslipidaemia that accompanies type 2 diabetes and is characterised by increased triglyceride levels and reduced high-density lipoprotein cholesterol concentrations also seems to contribute to this association. Recent years have witnessed an increased interest in postprandial lipidaemia, as a result of various prospective studies showing that non-fasting triglycerides predict the onset of arteriosclerotic cardiovascular disease better than fasting measurements do. Additionally, the use of certain specific postprandial particle markers, such as apolipoprotein B-48, makes it easier and more simple to approach the postprandial phenomenon. Despite this, only a few studies have evaluated the role of postprandial triglycerides in the development of peripheral arterial disease and type 2 diabetes. The purpose of this review is to examine the epidemiology and risk factors of peripheral arterial disease in type 2 diabetes, focusing on the role of postprandial triglycerides and particles.
