A feasibility study of a new approach to clinical radiosensitisation: hypothermia and hyperbaric oxygen in combination with pharmacological vasodilatation.
A feasibility study of a new approach to clinical radiosensitisation: hypothermia and hyperbaric oxygen in combination with pharmacological vasodilatation.
复制标题
临床放射增敏新方法的可行性研究：低温和高压氧结合药物血管舒张。
DOI：
10.1259/0007-1285-59-707-1093
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
J. Boniaszczuk
中科院分区：
文献类型：
--
作者：
R. Sealy;G. Harrison;D. Morrell;J. Korrûbel;A. Gregory;L. Barry;G. Blekkenhorst;E. Hering;A. Fataar;J. Boniaszczuk
有人提出，高压氧在临床情况下失败，因为在人类肿瘤中缺氧细胞的比例很高（大于33%）。本文综述了克服这一问题的方法。除了高压氧外，还提出了中度低温（30摄氏度），以使氧气在肿瘤中重新分布。本文介绍了一种适用于单人高压气瓶的外控静脉麻醉系统。在麻醉的患者中诱导药理学血管舒张，然后对患者进行液体加载和冷却。最初的单一致敏治疗是提倡的。29例晚期口腔癌患者完成了一个疗程的治疗，其中9例中有5例在2年后无病，21例中有10例在1年后无病，3例并发死亡。15个国家经历了局部失败。这一办法似乎是切实可行、安全和有希望的。
It is proposed that hyperbaric oxygen fails in the clinical situation due to a high proportion (greater than 33%) of hypoxic cells in human tumours. The means of overcoming this problem are reviewed. Additional to hyperbaric oxygenation, moderate hypothermia (30 degrees C) to allow redistribution of oxygen in the tumour is proposed. A system of externally controlled intravenous anaesthesia has been developed for the single-subject hyperbaric cylinder. Pharmacological vasodilatation is induced in the anaesthetised patient who is then fluid loaded and cooled. Initial single-sensitising treatments are advocated. Twenty-nine patients with advanced mouth cancer have completed a course of this treatment, of whom five of nine were free of disease after 2 years and 10 of 21 at 1 year, with three intercurrent deaths. Fifteen have experienced local failure. This approach would appear to be practical, safe and promising.