Pregabalin Abuse in Combination With Other Drugs: Monitoring Among Methadone Patients
Pregabalin Abuse in Combination With Other Drugs: Monitoring Among Methadone Patients
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DOI：
10.3389/fpsyt.2019.01022
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发表时间：
2020-02-11
影响因子：
4.7
通讯作者：
Gambelunghe, Cristiana
中科院分区：
文献类型：
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作者：
Lancia, Massimo;Gambelunghe, Angela;Gambelunghe, Cristiana
简介近年来，包括普瑞巴林（PGB）在内的精神活性处方药的非医疗使用有所增加。研究表明，美沙酮治疗方案中的多个吸毒者和患者以高剂量施用PGB，以达到欣快、减少戒断症状或增强美沙酮的效果。出于这些原因，需要对这些高风险个体进行准确的毒理学监测。材料与方法本研究调查了250例有阿片类药物依赖史的患者的发样中是否检测到PGB，并在毒理学监测下评估其美沙酮维持治疗的依从性。结果在所有头发样本中发现54/250的阿片类药物，而大麻在74/250的患者中存在，可卡因在21/250的患者中被检测到，苯二氮卓类药物在49/250的患者中被确定为非处方药。正如预期，美沙酮存在于所有250例患者（100%）。在35/250例患者（14%）的头发样本中发现了未经处方的PGB。其中，91.43%为男性，48.57%为
IntroductionIn recent years, there has been an increase in the non-medical use of psychoactive prescription drugs including pregabalin (PGB). Studies have shown that multiple drug users and patients in methadone treatment programs administered PGB at high dosages in order to achieve euphoria, reduce withdrawal symptoms, or potentiate the effects of methadone. For these reasons, accurate toxicological monitoring is required for these high-risk individuals. Materials and MethodsThe present study investigated whether PGB could be detected in the hair samples of 250 patients with a history of opiate dependency, and under toxicological surveillance assess their compliance with methadone maintenance therapy. ResultsOpiates were found in 54/250 of all hair samples, while cannabis was present in 74/250 patients, cocaine was detected in 21/250 patients, and benzodiazepines without prescription were identified in 49/250 patients. As expected, methadone was present in all 250 patients (100%). PGB without prescription was found in the hair samples of 35/250 patients (14%). Of these, 91.43% were male, 48.57% were