Rho effectors and reorganization of actin cytoskeleton
Rho effectors and reorganization of actin cytoskeleton
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DOI：
10.1016/s0014-5793(97)00317-7
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发表时间：
1997-06-23
期刊：
影响因子：
3.5
通讯作者：
Watanabe, N
中科院分区：
文献类型：
--
作者：
Narumiya, S;Ishizaki, T;Watanabe, N
小分子GTP酶Rho调节细胞黏附、胞质分裂和收缩等细胞过程，其生化机制尚不清楚，最近分离到几种GTP-Rho结合蛋白，其中p140mDia和p160ROCK可能作为Rho效应分子介导其对细胞骨架的作用，p140mDia通过在Rho作用部位招募肌动蛋白结合蛋白profilin来诱导肌动蛋白聚合，p160ROCK通过激活整合蛋白并利用基于肌球蛋白的收缩作用聚集它们来诱导焦点粘连和应力纤维。(C)1997年欧洲生化学会联合会。
The small GTPase Rho regulates several actomyosin-based cellular processes such as cell adhesion, cytokinesis and contraction, The biochemical mechanisms of these actions remain unknown, Recently, several GTP-Rho binding proteins were isolated, Among them, p140mDia and p160ROCK appear to work as Rho effectors mediating its action on the cytoskeleton, p140mDia induces actin polymerization by recruiting an actin binding protein, profilin, to the site of Rho action, p160ROCK induces focal adhesions and stress fibers by activating integrin and clustering them by the use of myosin-based contractility. (C) 1997 Federation of European Biochemical Societies.