Proton nuclear magnetic resonance imaging of acute experimental cerebral ischemia.
Proton nuclear magnetic resonance imaging of acute experimental cerebral ischemia.
复制标题
急性实验性脑缺血的质子核磁共振成像。
DOI：
10.1097/00004424-198307000-00010
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发表时间：
1983
影响因子：
6.7
通讯作者：
Hosobuchi,Y
中科院分区：
文献类型：
--
作者：
Mano,I;Levy,RM;Crooks,LE;Hosobuchi,Y
为了确定质子核磁共振（NMR）成像在记录急性缺血性梗死中的有效性，并描述缺血性损伤后前24小时内这些图像的变化，对单侧颈动脉结扎的沙鼠进行了连续NMR成像。无症状的动物或有症状的沙鼠的对照半球的信号强度，T1或T2弛豫时间没有显着变化。有症状的沙鼠的缺血半球的T1，特别是T2弛豫时间和相对信号强度和Hf（v）有显着增加。这些参数似乎在24小时内线性增加。最早在颈动脉结扎后3小时（我们的最早时间点），核磁共振就可以首先检测到缺血性病变。这些变化的生理意义进行了讨论。这些数据表明，核磁共振成像可能对人类急性脑缺血和梗死具有重要的诊断意义。
To determine the efficacy of proton nuclear magnetic resonance (NMR) imaging in documenting acute ischemic infarction and to characterize the changes in these images during the first 24 hours following the ischemic insult, serial NMR imaging was performed in gerbils that had undergone unilateral carotid artery ligation. No significant changes in the signal intensity, T1 or T2 relaxation times were noted for either asymptomatic animals or the control hemisphere of symptomatic gerbils. There was a significant increase in T1 and especially T2 relaxation times and in both the relative signal intensity and Hf (v) for the ischemic hemisphere of symptomatic gerbils. These parameters appeared to increase linearly over 24 hours. The ischemic lesion first could be detected by NMR as early as 3 hours after carotid artery ligation, our earliest time point. The physiologic significance of these changes is discussed. These data suggest that NMR imaging may have significant diagnostic importance for acute cerebral ischemia and infarction in man.