Simulated weightlessness to induce chronic hypoactivity of brain norepinephrine for exercise and stress studies.
Simulated weightlessness to induce chronic hypoactivity of brain norepinephrine for exercise and stress studies.
复制标题
模拟失重诱导大脑去甲肾上腺素慢性低活性，用于运动和压力研究。
DOI：
10.1097/00005768-199701000-00007
复制
发表时间：
1997
影响因子：
4.1
通讯作者：
Kastello,GK
中科院分区：
文献类型：
--
作者：
Sothmann,M;Kastello,GK
尽管运动训练和生理应激反应之间的关系的研究越来越多，但我们对脑神经化学的参与知之甚少。此外，已进行的为数不多的研究集中在神经化学功能正常的动物身上，这些动物暴露在急性应激源中。生物医学研究正在得出生理应激反应的低活性与某些医疗条件之间的联系。因此，需要一种能够显示慢性应激系统活动不足的动物模型。在这份报告中，我们描述了在动物和人类的实际失重和模拟失重情况下去甲肾上腺素变化的研究结果。有与大鼠一致的证据表明，14d的模拟失重会导致参与生理应激反应的特定脑干核团和周围组织中去甲肾上腺素的周转减少。对于大脑的其他区域，尤其是下丘脑，我们知之甚少。这些初步数据表明，模拟失重是一种方法，可以通过诱导去甲肾上腺素生物合成或释放的慢性低活动来研究作为干预的运动训练。
Although research on the relationship between exercise training and physiological stress reactivity is increasing, we know little about the involvement of brain neurochemistry. Moreover, the few studies that have been performed have concentrated on animals with normally functioning neurochemistry exposed to an acute stressor. Biomedical research is drawing an association between hypoactivation of the physiological stress response and certain medical conditions. As such, there is a need for an animal model that manifests a chronic hypoactivity of the stress system. In this report we describe the results from studies on norepinephrine changes with actual and simulated weightlessness in animals and humans. There is consistent evidence with rats that 14 d of simulated weightlessness produces reduced norepinephrine turnover in selected brainstem nuclei and peripheral tissue mediating the physiological stress response. Little is known about other brain regions, particularly the hypothlamus. These preliminary data suggest that simulated weightlessness is one method by which a chronic hypoactivity of norepinephrine biosynthesis or release might be induced to study exercise training as an intervention.