INTERACTIONS OF ATOVAQUONE WITH OTHER ANTIMALARIAL-DRUGS AGAINST PLASMODIUM-FALCIPARUM IN-VITRO
INTERACTIONS OF ATOVAQUONE WITH OTHER ANTIMALARIAL-DRUGS AGAINST PLASMODIUM-FALCIPARUM IN-VITRO
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DOI：
10.1006/expr.1995.1049
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发表时间：
1995-05-01
影响因子：
2.1
通讯作者：
GUTTERIDGE, WE
中科院分区：
文献类型：
--
作者：
CANFIELD, CJ;PUDNEY, M;GUTTERIDGE, WE
进行了一系列恶性疟原虫体外药物敏感性研究，以评价阿托伐醌与其他抗疟药物的组合，从而确定固定组合的潜在伙伴。衍生的等效线图表明，药物相互作用范围从拮抗作用，通过添加到协同作用。特别值得注意的是喹啉和青蒿素类似物，它们都是拮抗性的，而双胍和四环素则显示出协同作用。氯胍作为阿托伐醌的伙伴，与四环素作为后备，成为目前最有前途的抗疟药。(C)出版社：Academic Press
A series of Plasmodium falciparum in vitro drug sensitivity studies were conducted in order to evaluate atovaquone in combination with other antimalarial drugs and thus to identify a potential partner for a fixed combination. The derived isobolograms indicated that drug interactions ranged from antagonism through addition to synergy. Of particular note were the quinolines and artemisinin analogues, which were all antagonistic, and the biguanides and tetracycline, which showed synergy. Proguanil emerged as the most promising of the current antimalarials as a partner for atovaquone in a fixed combination, with tetracycline as back-up. (C) 1995 Academic Press, Inc.