Feeding of Lactobacillus sobrius reduces Escherichia coli F4 levels in the gut and promotes growth of infected piglets
Feeding of Lactobacillus sobrius reduces Escherichia coli F4 levels in the gut and promotes growth of infected piglets
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DOI：
10.1111/j.1574-6941.2008.00517.x
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发表时间：
2008-12-01
影响因子：
4.2
通讯作者：
de Vos, Willem M.
中科院分区：
文献类型：
--
作者：
Konstantinov, Sergey R.;Smidt, Hauke;de Vos, Willem M.
哺乳动物肠道中的微生物群落通常被视为治疗和预防干预的重要潜在目标。本研究的目的是确定是否可以通过使用Lactobacillus sobrius DSM 16698进行益生菌治疗来抵消幼龄动物中的肠致病性大肠杆菌（ETEC）F4感染。试验分三个随机重复进行，每个重复16头仔猪，包括对照组和L。sobrius喂养组，均用ETEC进行实验性攻击。在整个试验期间，定期监测动物的健康状况、体重和微生物参数。益生菌补充剂含有L.断奶后直接饲喂仔猪时，sobrius可显着降低回肠中ETEC的水平。相比之下，益生菌组仔猪粪便含水量增加的天数显著更高。然而，在接受益生菌L的动物中也观察到改善的日增重。相对于对照进食组，数据表明L. sobrius可能是降低E.大肠杆菌F4定殖，并可能提高感染仔猪的增重。
The microbial community in the guts of mammals is often seen as an important potential target in therapeutic and preventive interventions. The aim of the present study was to determine whether enterotoxigenic Escherichia coli (ETEC) F4 infection in young animals might be counteracted by a probiotic treatment with Lactobacillus sobrius DSM 16698. The experiment was conducted in three randomized consecutive replications, each consisting of 16 piglets, and including a control group and an L. sobrius fed group, both experimentally challenged with ETEC. During the entire trial, the animals' health status, body weight, and microbial parameters were monitored periodically. Probiotic supplementation containing L. sobrius significantly reduced the levels of ETEC in the ileum when fed directly to piglets after weaning. In contrast, the number of days when the piglets had an increased faecal water content was significantly higher in the probiotic group. Nevertheless, an improved daily weight gain was also observed in the animals that received probiotic L. sobrius relative to the control fed group. The data indicate that L. sobrius may be effective in the reduction of the E. coli F4 colonization and may improve the weight gain of infected piglets.