Electrodermal predictors of functional outcome and negative symptoms in schizophrenia.
Electrodermal predictors of functional outcome and negative symptoms in schizophrenia.
复制标题
精神分裂症功能结果和阴性症状的皮肤电预测因子。
DOI：
10.1111/j.1469-8986.2005.00300.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Nuechterlein,KeithH
中科院分区：
文献类型：
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作者：
Schell,AnneM;Dawson,MichaelE;Rissling,Anthony;Ventura,Joseph;Subotnik,KennethL;Gitlin,MichaelJ;Nuechterlein,KeithH
在78名年轻的、近期发作的门诊患者中研究了皮肤电变量预测精神分裂症阴性症状和功能结局的能力。患者在标准化药物治疗后病情稳定，基本上没有精神病症状。在1年随访时，较高水平的强直性（皮肤电导水平，非特异性皮肤电导反应率）和阶段性（皮肤电导定向反应的数量）活动与更多的阴性症状以及较差的社会和职业结局相关。这种模式在男性和女性患者以及老年和年轻患者中均可见。结果被解释为表明，高水平的觉醒和过度反应的环境可能会干扰有效的认知处理精神分裂症，导致不良的结果，和阴性症状可能部分作为一种手段，应对过度觉醒。
The ability of electrodermal variables to predict negative symptoms and functional outcome over a 1‐year period in schizophrenia was investigated in 78 young, recent‐onset outpatients. Patients were stabilized on standardized medication and largely free of psychotic symptoms. Higher levels of both tonic (skin conductance level, nonspecific skin conductance response rate) and phasic (number of skin conductance orienting responses) activity were associated with more negative symptoms and with a combination of poorer social and occupational outcome at 1‐year follow‐up. This pattern was seen in both male and female patients, and in older and younger patients. Results are interpreted as suggesting that high levels of arousal and overreactivity to the environment may interfere with efficient cognitive processing in schizophrenia, contributing to poor outcome, and that negative symptoms might partially serve as a means of coping with overarousal.