Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid.
Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid.
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花生四烯酸的脂氧合酶代谢物刺激结肠分泌。
DOI：
10.1126/science.6810465
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Siegel,MI
中科院分区：
文献类型：
--
作者：
Musch,MW;Miller,RJ;Field,M;Siegel,MI
5-羟基过氧二十碳四烯酸（5-HPETE）和5-羟基二十碳四烯酸（5-HETE）均可增加离体兔结肠粘膜的短路电流（Isc）。氯-36通量的测量表明，ISC对5-HPETE的反应是由于刺激活性氯分泌。9-、11-和12-HPETE和白三烯C4和B4使Iscor非常小地增加或不增加。与兔结肠中的结果相反，HPETE、HETE或白三烯在兔回肠粘膜中均无效。5-HPETE在兔结肠中的作用不受米帕林的影响，但可被吲哚美辛部分阻断。这些结果表明，阻断环氧合酶和脂氧合酶的药物可能是结肠炎患者有效的抗结肠炎药物。
Both 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) increased the short-circuit current (Isc) in rabbit colonic mucosa mounted in vitro in Ussing chambers. Measurements of chlorine-36 fluxes indicated that the Iscresponse to 5-HPETE is due to stimulation of active chlorine secretion. 9-, 11-, and 12-HPETE's and leukotrienes C4and B4produced either very small increases in Iscor no increase. In contrast to results in rabbit colon, no HPETE, HETE, or leukotriene was effective in rabbit ileal mucosa. The effects of 5-HPETE in the rabbit colon were unaffected by mepacrine, but could be partially blocked by indomethacin. These results suggest that drugs which block both cyclooxygenase and lipoxygenase may be effective antidiarrheals in patients with colitis.