Virus-specific IgG and IgM antibodies in normal and immunocompromised subjects infected with cytomegalovirus.
Virus-specific IgG and IgM antibodies in normal and immunocompromised subjects infected with cytomegalovirus.
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感染巨细胞病毒的正常和免疫功能低下受试者的病毒特异性 IgG 和 IgM 抗体。
DOI：
10.1093/infdis/145.2.191
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Merigan,TC
中科院分区：
文献类型：
--
作者：
Rasmussen,L;Kelsall,D;Nelson,R;Carney,W;Hirsch,M;Winston,D;Preiksaitis,J;Merigan,TC
用固相放射免疫法测定血清中抗人巨细胞病毒(CMV)抗体的水平。补体结合试验阳性的个体始终有放射免疫分析可检测到的免疫球蛋白滴度，但没有明显的定量关系。IgM滴度升高被认为是CMV感染的特异性，因为其他疱疹病毒感染患者的血清不会发生交叉反应。在单核细胞增多症患者中，CMV IgM抗体滴度升高与活动性感染相关(P<；0.01)，且在病毒血症期间最高。有症状感染期间和感染后的CMV抗体滴度与无症状阳性者相似。在心脏移植受者的初次感染和再激活感染中均观察到CMV特异性IgM的增加。在少数反复出现症状性疾病的心脏移植受者中，IgM滴度在病毒尿时较低，且不随CMV组织受累而升高，提示IgM定量缺陷可能与CMV感染的严重程度有关。
Levels of IgG and IgM antibodies to human cytomegalovirus (CMV) were measured using a solid-phase radioimmunoassay. Individuals positive by complement-fixation test consistently had detectable IgG titers by radioimmunoassay, but no quantitative relationship was apparent. An elevated IgM titer was considered specific for CMV infection because sera from individuals with other herpesvirus infections did not crossreact. In patients with mononucleosis, elevated titers of IgM antibody to CMV correlated (P< 0.(01) with active infection and were highest during viremia. Titers of IgG antibody to CMV during and after symptomatic infection were similar to those of asymptomatic positive individuals. Increases in CMV-specific IgM were observed in both primary and reactivated infections in cardiac transplant recipients. In a smal group of cardiac transplant recipients with recurrent symptomatic disease, IgM titers were low at the time of viruria and did not increase with CMV tissue involvement, a result which suggests that quantitative deficiencies in IgM may be related to the severity of CMV infections.