Pathophysiology of right ventricular failure.
Pathophysiology of right ventricular failure.
复制标题
DOI：
10.1097/01.ccm.0000296265.52518.70
复制
发表时间：
2008-01-01
影响因子：
8.8
通讯作者：
Greyson, Clifford R
中科院分区：
文献类型：
--
作者：
Greyson, Clifford R
右心室衰竭可以定义为心脏的右心室在正常的中心静脉压下无法提供足够的血流通过肺循环。重症监护专家在实践中经常遇到右心室衰竭，但直到最近，右心室衰竭作为主要的临床实体还很少受到考虑。事实上，目前还没有一份针对右心室衰竭的公开实践指南。右心室衰竭通常是由于右心室压力超负荷和右心室游离壁收缩异常共同造成的。由于右心室生理学的独特方面，失代偿可能会突然发生并且是灾难性的。本综述将重点关注重症监护环境中急性右心室衰竭的病理生理学，并总结可用的有限管理方案。
Right ventricular failure may be defined as the inability of the right ventricle of the heart to provide adequate blood flow through the pulmonary circulation at a normal central venous pressure. Critical care specialists encounter right ventricular failure routinely in their practice, but until recently right ventricular failure as a primary clinical entity received scant consideration. Indeed, there is still not a single published practice guideline focused on right ventricular failure. Right ventricular failure is usually due to a combination of right ventricular pressure overload and contractile abnormalities of the right ventricular free wall. Decompensation may occur abruptly and catastrophically because of unique aspects of right ventricular physiology. This review will focus on the pathophysiology of acute right ventricular failure in the critical care setting and summarize the limited management options available.