Regulation of protein function: Crystal packing interfaces and conformational dimerization
Regulation of protein function: Crystal packing interfaces and conformational dimerization
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蛋白质功能的调节：晶体堆积界面和构象二聚化
DOI：
10.1021/bi800125h
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发表时间：
2008-06-24
期刊：
影响因子：
2.9
通讯作者：
Dennison, Christopher
中科院分区：
文献类型：
--
作者：
Crowley, Peter B.;Matias, Pedro M.;Dennison, Christopher
蛋白质间电子传递的公认观点涉及供体和受体氧化还原位点之间的分子扩散。一个新兴的替代假设是，有效的远程电子传输可以通过蛋白质排列在超分子组件。在这项研究中，我们已经调查了晶体包装接口在三种晶体形式的质体蓝素，光合电子传递链的一个组成部分，并讨论其潜在的相关性在体内的超分子组件。这些晶体中与对称性相关的蛋白质链具有Cu-Cu分离，
The accepted view of interprotein electron transport involves molecules diffusing between donor and acceptor redox sites. An emerging alternative hypothesis is that efficient long-range electron transport can be achieved through proteins arranged in supramolecular assemblies. In this study, we have investigated the crystal packing interfaces in three crystal forms of plastocyanin, an integral component of the photosynthetic electron transport chain, and discuss their potential relevance to in vivo supramolecular assemblies. Symmetry-related protein chains within these crystals have Cu-Cu separations of