Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development
Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development
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DOI：
10.1126/science.1118875
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发表时间：
2006-01-06
期刊：
影响因子：
56.9
通讯作者：
Helariutta, Y
中科院分区：
文献类型：
--
作者：
Mähönen, AP;Bishopp, A;Helariutta, Y
形成运输组织(木质部和韧皮部)和中间多能原形成层组织的细胞系起源于根尖附近的干细胞。我们证明，在拟南芥中，细胞分裂素植物激素负向调节原生木质部的规格。AHP6是一种抑制假磷转运蛋白，它中和细胞分裂素信号，允许原生木质部的形成。相反，细胞分裂素信号负向调节AHP6表达的空间域。因此，通过控制细胞谱系的特性，细胞分裂素信号与其空间特异性调节物的相互作用在血管发育过程中调节细胞谱系的增殖和分化，展示了先前未知的分生组织组织调控电路。
The cell lineages that form the transporting tissues (xylem and phloem) and the intervening pluripotent procambial tissue originate from stem cells near the root tip. We demonstrate that in Arabidopsis, cytokinin phytohormones negatively regulate protoxylem specification. AHP6, an inhibitory pseudophosphotransfer protein, counteracts cytokinin signaling, allowing protoxylem formation. Conversely, cytokinin signaling negatively regulates the spatial domain of AHP6 expression. Thus, by controlling the identity of cell lineages, the reciprocal interaction of cytokinin signaling and its spatially specific modulator regulates proliferation and differentiation of cell lineages during vascular development, demonstrating a previously unrecognized regulatory circuit underlying meristem organization.