A humoral stress response protects Drosophila tissues from antimicrobial peptides
A humoral stress response protects Drosophila tissues from antimicrobial peptides
复制标题
体液应激反应保护果蝇组织免受抗菌肽的侵害
DOI：
10.1101/2023.07.24.550293
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Rommelaere S
中科院分区：
文献类型：
--
作者：
Rommelaere S
一个有效的免疫系统必须在不造成过多附带组织损伤的情况下，对多种病原体提供保护。虽然免疫效应物已经被很好地表征，但我们对保护宿主免受自身免疫反应的恢复机制知之甚少。抗菌肽（AMPs）是一种小的阳离子肽，通过靶向带负电荷的微生物膜来促进先天防御。虽然对病原体有保护作用，但amp对宿主细胞具有细胞毒性。在这里，我们揭示了应激诱导蛋白家族Turandots，保护果蝇呼吸系统免受amp的影响，增加了对应激的恢复能力。缺乏图兰朵基因的果蝇由于amp诱导的气管凋亡而易受环境应激的影响。图兰朵蛋白结合到宿主细胞膜上，并掩盖带负电荷的磷脂，保护它们免受阳离子孔隙形成的amp的影响。总的来说，这些数据表明图兰朵应激蛋白减轻AMP对宿主组织的细胞毒性，从而提高其功效。
7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect theDrosophilarespiratory system from AMPs, increasing resilience to stress. Flies lackingTurandotgenes are susceptible to environmental stresses due to AMP-induced tracheal apoptosis. Turandot proteins bind to host cell membranes and mask negatively charged phospholipids, protecting them from cationic pore-forming AMPs. Collectively, these data demonstrate that Turandot stress proteins mitigate AMP cytotoxicity to host tissues and therefore improve their efficacy.
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影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
通讯作者：
Hassabis D
影响因子：
21.3
作者：
Tamamouna V;Rahman MM;Petersson M;Charalambous I;Kux K;Mainor H;Bolender V;Isbilir B;Edgar BA;Pitsouli C
通讯作者：
Pitsouli C
影响因子：
5.8
作者：
Park YJ;Kim S;Shim HP;Park JH;Lee G;Kim TY;Jo MC;Kwon AY;Lee M;Lee S;Yeo J;Chung HL;Bellen HJ;Kwon SH;Jeon SH
通讯作者：
Jeon SH
影响因子：
2.1
作者：
Brun, S;Vidal, S;Lemaitre, B
通讯作者：
Lemaitre, B
影响因子：
2.7
作者：
Shen Y;Bax A
通讯作者：
Bax A