CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway
CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway
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基于 Shh 信号通路，CdSe/ZnS 量子点损害动物模型中前两代胎盘生长
DOI：
10.3390/nano9020257
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发表时间：
2019
期刊：
影响因子：
5.3
通讯作者：
Xu Hengyi
中科院分区：
文献类型：
--
作者：
Hong Wuding;Kuang Huijuan;He Xingping;Yang Lin;Yang Pengfei;Chen Bolu;Aguilar Zoraida P.;Xu Hengyi
尽管量子点在生物医学领域有着广阔的应用前景，但其体内毒性，特别是跨代毒性的研究却很少。研究了昆明种小鼠围产期（GD 13-PND 5）暴露于含镉量子点（CdSe/ZnS QDs）和氯化镉（CdCl 2）后，母体状况、妊娠结局以及亲代（P0）到子代（F3）的胎儿发育情况。结果表明，CdSe/ZnS量子点诱导胎盘损伤的P0和减少胎盘直径在F1和F2。在F1和F2代，CdSe/ZnS量子点处理组的体重增长下降。此外，CdSe/ZnS量子点显着改变了Shh信号通路中的关键基因的表达。总体而言，这项研究表明，在围产期暴露的CdSe/ZnS量子点损害胎盘生长的前两代，但不是在第三代。CdSe/ZnS量子点的毒性作用可能是通过影响Shh信号通路实现的。
The toxicity, especially the transgenerational toxicity of quantum dots (QDs) in vivo, is still scarcely understood in spite of great promising applications of QDs in biomedicine. In this study, the maternal status, pregnancy outcome, and fetus development of parental generation (P0) to offspring in three generations (F3) were investigated after Kunming mice perinatal (GD 13-PND 5) exposure to Cd containing QDs (CdSe/ZnS QDs) and CdCl2. The results show CdSe/ZnS QDs induced placenta injuries in P0 and diminished placenta diameters in F1 and F2. Bodyweight growth decreased in the CdSe/ZnS QDs treatment group in the F1 and F2 generation. Additionally, CdSe/ZnS QDs significantly altered the expression of key genes in the Shh signal pathway. Overall, this study exhibited that the CdSe/ZnS QDs exposure during perinatal period impaired placenta growth in the first two generations, but not on the third generation. The toxicological actions of the CdSe/ZnS QDs might be through the effects on the Shh signal pathway.