Prognostic significance of perigastric tumor deposits in patients with primary gastric cancer
Prognostic significance of perigastric tumor deposits in patients with primary gastric cancer
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DOI：
10.1186/s12893-017-0280-4
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发表时间：
2017-07-19
期刊：
影响因子：
1.9
通讯作者：
Huang, Chang-Ming
中科院分区：
文献类型：
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作者：
Anup, Shrestha;Lu, Jun;Huang, Chang-Ming
背景：胃周肿瘤沉积(TDS)在原发性胃癌中的存在及其预后意义尚未得到广泛研究。方法：2005年至2010年，福建医科大学附属福州协和医院胃外科收治的胃大部肿瘤患者1 250例，均行R0期胃切除术。在1250名患者中，132名患者被确定为胃周TDS。结果：在1250例行R0胃切除术的胃癌患者中，132例(10.5%)出现胃周TDS。男性94例(71.21%)，女性38例(28.79%)(2.47：1)。平均年龄57.21岁。两组的临床病理特征吻合较好。单因素分析显示，合并和不合并TDS患者的总生存率差异有统计学意义(p0.05)，但当将每组胃癌组与胃周TD组进行比较时，T4期生存率与TDS患者的T4期生存率非常接近。结论：胃周TDS是预测胃癌预后的独立因素，可被认为是浆膜侵犯的一种形式。我们建议TDS应纳入TNM分期系统，以获得更好的结果。
Background: The presence and the prognostic significance of perigastric tumor deposits (TDs) in primary gastric cancer have not been extensively studied. The aim of this study was to evaluate the prognostic significance perigastric TDs in primary gastric cancer.Methods: From 2005 to 2010, 1250 patients underwent R0 gastrectomy at the Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China. Out of 1250 patients, 132 patients with perigastric TDs were identified. Additionally, 132 patients with staged matched gastric cancer without tumor deposits were selected as a control group.Results: Perigastric TDs were observed in 132 (10.5%) of the 1250 patients with gastric cancer who underwent R0 gastrectomy. There were 94 males (71.21%) and 38 females (28.79%) (2.47:1). The mean age was 57.21 years. Clinicopathologic characteristics between the two groups matched well. There was a significant difference in the overall survival of those with and without TDs by univariate (p0.05); however, when comparing each pT tumor group with the perigastric TD group, the stage T4 survival rate was very similar to that observed in patients with TDs.Conclusions: Perigastric TDs are an independent predictive prognostic factor for gastric cancer and may be appropriately considered a form of serosal invasion. We suggest that TDs should be included in TNM staging system for better outcomes.