Effects of Cacao Liquor Polyphenols on Cardiovascular and Autonomic Nervous Functions in Hypercholesterolaemic Rabbits
Effects of Cacao Liquor Polyphenols on Cardiovascular and Autonomic Nervous Functions in Hypercholesterolaemic Rabbits
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DOI：
10.1111/j.1742-7843.2008.00331.x
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发表时间：
2008-12-01
影响因子：
3.1
通讯作者：
Tsubone, Hirokazu
中科院分区：
文献类型：
--
作者：
Akita, Megumi;Kuwahara, Masayoshi;Tsubone, Hirokazu
许多流行病学研究表明，多酚可以降低心血管疾病的死亡风险。本研究验证了可可液多酚具有恢复家族性高胆固醇血症动物模型心血管和自主神经功能的特性的假设。将雄性Kurosawa和Kusanagi高胆固醇血症家兔饲养在单独的笼子中，饲养室维持12小时光照：黑暗周期（8：00开灯，20：00关灯）。在3月龄时，将它们分成两组（标准饮食和可可液多酚），动物每天接受100 g各自的饮食，并随意提供自来水。通过遥测系统测量心率和血压。为了阐明自主神经功能，测量心率变异性、压力反射敏感性和自主神经张力的功率谱分析。饮食给予可可液多酚6个月后，心率和血压降低，但血浆脂质浓度不变。可可液多酚组的主动脉粥样硬化病变面积明显小于标准饮食组。标准饮食组家兔心率变异性高频功率随增龄显著降低，而可可液多酚组短期与长期治疗组无显著差异。此外，可可液多酚保留副交感神经紧张，虽然在标准饮食组显着降低与老化。我们得出结论，可可液多酚可能发挥重要作用，保护心血管和自主神经功能。
Many epidemiological studies have shown that polyphenols can reduce the risk of mortality from cardiovascular diseases. This study tested the hypothesis that cacao liquor polyphenols have the properties to restore the cardiovascular and autonomic nervous function in an animal model of familial hypercholesterolaemia. Male Kurosawa and Kusanagi-hypercholesterolaemic rabbits were housed in individual cages in a room where a 12-hr light:dark cycle (lights-on at 8:00 and lights-off at 20:00) was maintained. At 3 months of age, they were divided into two groups (standard diet and cacao liquor polyphenol) and the animals received 100 g of the respective diets per day and were provided with tap water ad libitum. Heart rate and blood pressure were measured by a telemetry system. To clarify the autonomic nervous function, power spectral analysis of heart rate variability, baroreflex sensitivity and autonomic nervous tone were measured. After 6 months of dietary administration of cacao liquor polyphenols, heart rate and blood pressure were lowered but plasma lipid concentrations were unchanged. The area of atherosclerotic lesions in the aorta in the cacao liquor polyphenol group was significantly smaller than that in the standard diet group. The high-frequency power of heart rate variability in the rabbits in the standard diet group was significantly decreased with ageing, but that in the cacao liquor polyphenol group was not different between short-term and long-term treatment. Moreover, cacao liquor polyphenols preserved parasympathetic nervous tone, although that in the standard diet group was significantly decreased with ageing. We conclude that cacao liquor polyphenols may play an important role to protect cardiovascular and autonomic nervous functions.