Neuro-epithelial-ILC2 crosstalk in barrier tissues.
Neuro-epithelial-ILC2 crosstalk in barrier tissues.
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DOI：
10.1016/j.it.2022.09.006
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发表时间：
2022-10
影响因子：
16.8
通讯作者：
Ziyi Yin;Y. Zhou;H. Turnquist;Quan Liu
中科院分区：
文献类型：
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作者：
Ziyi Yin;Y. Zhou;H. Turnquist;Quan Liu
第2组先天性淋巴样细胞（ILC2）有助于维持哺乳动物屏障组织的稳态。我们综述了ILC2如何整合上皮信号和神经源性成分，以保护组织微环境和调节炎症。覆盖在屏障组织（包括皮肤、肺和肠）上的上皮产生引起ILC2活化的上皮细胞因子。交感神经、副交感神经、感觉和肠纤维释放神经信号来调节ILC 2功能。我们还强调了最近的研究结果，表明神经上皮细胞ILC2串扰及其在免疫，炎症和决议，组织修复和恢复稳态的影响。我们进一步讨论了以ILC2为中心的神经上皮免疫细胞相互作用和治疗靶向的假定领域的干扰的致病作用。
Group 2 innate lymphoid cells (ILC2s) contribute to the maintenance of mammalian barrier tissue homeostasis. We review how ILC2s integrate epithelial signals and neurogenic components to preserve the tissue microenvironment and modulate inflammation. The epithelium that overlies barrier tissues, including the skin, lungs, and gut, generates epithelial cytokines that elicit ILC2 activation. Sympathetic, parasympathetic, sensory, and enteric fibers release neural signals to modulate ILC2 functions. We also highlight recent findings suggesting neuro–epithelial–ILC2 crosstalk and its implications in immunity, inflammation and resolution, tissue repair, and restoring homeostasis. We further discuss the pathogenic effects of disturbed ILC2-centered neuro–epithelial–immune cell interactions and putative areas for therapeutic targeting.