Assessment of the transferrin index in screening heavy drinkers from a general practice.
Assessment of the transferrin index in screening heavy drinkers from a general practice.
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从一般实践中筛选重度饮酒者时评估转铁蛋白指数。
DOI：
10.1111/j.1530-0277.1989.tb00376.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
J. Weill
中科院分区：
文献类型：
--
作者：
R. Poupon;F. Schellenberg;B. Nalpas;J. Weill
本研究的目的是评估转铁蛋白（Tf）指数在筛选重度饮酒者中的表现，并将其与谷氨酰转肽酶（GGT）的表现进行比较。在家庭医生诊所招募的173名受试者（49%为男性）中测定Tf指数、GGT和转氨酶活性（年龄：54 +/- 1.5岁；每日酒精摄入量：32 +/- 3.5 g；平均+/- SEM）。用聚丙烯酰胺凝胶等电聚焦和免疫固定法测定Tf亚组。Tf指数为5.7比5.4，即Tf指数，被用作过度饮酒的标志，临界值为7%。通过面对面的访谈来评估酒精摄入量。过量饮酒者被定义为每日酒精摄入量超过80克，持续时间至少2年；20人被归类为过度饮酒者（酒精摄入量：92-232克/天）。除4例外，其余均有正常的转氨酶活性，表明该样本中肝损害的患病率较低。Tf指数的敏感性为45%，特异性为89%，阳性预测值为35%，阴性预测值为92%。GGT对应的结果分别为52%、80%、27%和92%。通过kappa系数（kappa）评估Tf指数与GGT之间的一致性，kappa系数为0.22，表明两个标记在选择过度饮酒者时一致性较差（完全关联：kappa = 1，无关联：kappa = 0）。
The aim of this study was to assess the performance of the transferrin (Tf) index in screening heavy drinkers and to compare its performance to that of gamma glutamyl transpeptidase (GGT). Tf index, GGT, and transaminase activities were determined in a group of 173 subjects (49% males) recruited in a family doctor's practice (age: 54 +/- 1.5 yr; daily alcohol intake: 32 +/- 3.5 g; mean +/- SEM). Tf subfractions were quantified by isoelectric focusing and immunofixation on polyacrylamide gel. The Tf pl 5.7 to 5.4 ratio, or Tf index, was used as a marker of excessive drinking, with a cut-off point at 7%. Alcohol consumption was assessed through a face-to-face interview. Excessive drinkers were defined as those with a daily alcohol intake greater than 80 g over at least 2 years; 20 were classified as excessive drinkers (alcohol consumption: 92-232 g/day). All but four had normal transaminase activities indicating the low prevalence of hepatic impairments in this sample. The Tf index was found to have a sensitivity of 45%, specificity 89%, positive predictive value 35%, negative predictive value 92%. The corresponding results for GGT were 52%, 80%, 27%, and 92%, respectively. Concordance between the Tf index and GGT was assessed by the kappa coefficient (kappa) which was 0.22 indicating poor agreement between the two markers in selecting excessive drinkers (perfect association: kappa = 1, no association: kappa = 0).