COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder
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DOI：
10.2147/ndt.s199598
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发表时间：
2019-01-01
影响因子：
3.2
通讯作者：
Yoshimura, Reiji
中科院分区：
文献类型：
--
作者：
Otsuka, Yuka;Kakeda, Shingo;Yoshimura, Reiji
目的：与健康受试者（HS）相比，重度抑郁症（MDD）患者表现出体积差异，影响边缘系统、皮质、皮质下和白质等多个区域的体积变化。儿茶酚-O-甲基转移酶（COMT）是一种催化内源性儿茶酚胺的甲基化酶。据报道，COMT 的 Val158Met 多态性会影响多巴胺 (DA) 水平，而多巴胺 (DA) 水平在精神疾病中发挥重要作用。然而，DA 水平、COMT 基因型和大脑形态之间的关系是复杂且有争议的。在之前调查海马亚区的研究中，MDD 患者的大脑异常最严重的是 Cornu Ammonis (CA)1 和下托，其次是 CA2-3。我们前瞻性地证明了 Val158Met COMT 基因 (rs4680) 的单核苷酸多态性与初治 MDD 患者海马亚区之间的关系。 患者和方法：在这项研究中，我们比较了 27 名 MDD 患者和 42 名 HS，根据 COMT 基因型将他们分组。通过对高分辨率磁共振成像 (MRI) 结果进行 FreeSurfer 统计分析，评估与 CA1 和下托体积以及全脑皮质厚度相关的诊断、基因型和基因型-诊断相互作用的影响。 结果：结果显示，右侧下托（海马的一个组成部分）的诊断效果和基因型之间存在统计学上显着的交互作用。结论：此 Val158Met COMT 多态性可能影响初治首发 MDD 患者的下托体积。
Purpose: Compared with healthy subjects (HS), patients with major depressive disorder (MDD) exhibit volume differences that affect the volume changes in several areas such as the limbic, cortical, subcortical, and white matter. Catechol-O-methyltransferase (COMT) is a methylation enzyme that catalyzes endogenous catecholamines. The Val158Met polymorphism of COMT has been reported to affect the dopamine (DA) levels, which plays an important role in psychiatric diseases. However, the relationships among both DA levels, COMT genotype, and brain morphology are complicated and controversial. In previous studies that investigated the hippocampal subfields, the greatest brain abnormalities in MDD patients were observed in Cornu Ammonis (CA)1 and the subiculum, followed by that in CA2-3. We have prospectively demonstrated the relationship between the single-nucleotide polymorphism of the Val158Met COMT gene (rs4680) and the hippocampal subfields in drug-naive MDD patients.Patients and methods: In this study, we compared 27 MDD patients and 42 HS who were divided into groups based on their COMT genotype. The effects of the diagnosis, genotype, and genotype-diagnosis interaction related to CA1 and the subiculum volumes, as well as the whole-brain cortical thickness, were evaluated by performing a FreeSurfer statistical analysis of high-resolution magnetic resonance imaging (MRI) findings.Results: The results revealed that there was a statistically significant interaction between the effects of diagnosis and genotype on the right subiculum (a component of the hippocampus).Conclusion: This Val158Met COMT polymorphism may influence the subiculum volume in drug-naive, first-episode MDD patients.