Bioactive star gels
Bioactive star gels
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DOI：
10.1021/cm0615370
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发表时间：
2006-11-28
影响因子：
8.6
通讯作者：
Vallet-Regi, M.
中科院分区：
文献类型：
--
作者：
Manzano, M.;Arcos, D.;Vallet-Regi, M.
采用溶胶-凝胶法合成了适用于骨修复的星星凝胶杂化材料。为了确定网络的连通性和钙离子在杂化网络中的位置，研究了不同组成的星星凝胶的物理和化学性质。体外生物活性测试证明，星星凝胶在与模拟体液接触的表面上形成磷灰石样相，尽管该性质取决于Si/Ca比。最后，机械性能的研究表明，星星凝胶的刚性低于传统的生物活性玻璃，显示出类似的断裂韧性值比皮质骨，并指出优良的长期疲劳行为。
Star gels hybrid materials, suitable for use in bone repair, have been synthesized by the sol-gel method, incorporating a calcium alkoxide to the synthesis process. To determine the network connectivity and the Ca2+ cation location into the hybrid network, the physical and chemical properties of star gels with different compositions have been studied. In vitro bioactivity tests evidence that the star gels develop an apatite-like phase on their surface in contact with simulated body fluid, although this property depends on the Si/Ca ratio. Finally, the study of mechanical properties demonstrated that star gels are less rigid than conventional bioactive glasses, show similar fracture toughness values than cortical bone, and point to excellent long-term fatigue behavior.