Detection and application of circulating tumor cell and circulating tumor DNA in the non-small cell lung cancer
Detection and application of circulating tumor cell and circulating tumor DNA in the non-small cell lung cancer
复制标题
循环肿瘤细胞和循环肿瘤DNA在非小细胞肺癌中的检测及应用
DOI：
--
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Fan Songqing
中科院分区：
文献类型：
--
作者：
Zhang Yuting;Zheng Hongmei;Zhan Yuting;Long;Mengping;Liu Sile;Lu Junmi;Zang Hongjing;Fan Songqing
非小细胞肺癌（NSCLC）是男性和女性癌症相关死亡的主要原因。癌细胞从原发肿瘤脱落并扩散到远处器官的能力是癌症患者死亡的主要原因。循环肿瘤细胞（CTCs）和循环肿瘤DNA（ctDNA）的检测是液体活检的重要组成部分，有助于诊断、治疗和预后，特别是识别非小细胞肺癌的靶向突变。本文就CTC和ctDNA的检测及其在非小细胞肺癌诊断、预后评估和指导靶向治疗中的应用作一综述。
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in both men and women. The ability of cancer cells to break-off from the primary tumor and spread to distant organs is the main cause of death of cancer patients. The detection of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) is a considerable part of liquid biopsy, which contributes to the diagnosis, treatment and prognosis, and especially to identify the targetable mutations of NSCLC. This review is to discuss the detection and application of CTC and ctDNA in the diagnosis, prognostic evaluation and guiding targeted therapy of NSCLC.