HIGH-RESOLUTION OF HUMAN EVOLUTIONARY TREES WITH POLYMORPHIC MICROSATELLITES
HIGH-RESOLUTION OF HUMAN EVOLUTIONARY TREES WITH POLYMORPHIC MICROSATELLITES
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DOI：
10.1038/368455a0
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发表时间：
1994-03-31
期刊：
影响因子：
64.8
通讯作者：
CAVALLISFORZA, LL
中科院分区：
文献类型：
--
作者：
BOWCOCK, AM;RUIZLINARES, A;CAVALLISFORZA, LL
高变基因座的遗传变异被广泛用于连锁分析1和个体识别2，并可能用于群体间研究2 -5。在这里，我们表明，多态性微卫星（主要是CA重复）允许树的人类个体构建，反映他们的地理起源具有显着的准确性。这是通过分析每个个体的大量基因座来实现的，尽管群体之间存在等位基因频率的小变化6，7。可靠的进化关系也可以在人类种群之间的比较中建立起来，但在类人猿物种之间却不能，这可能是因为等位基因长度变异的限制。在人类种群中，非洲的微卫星多样性最高，这与其他核标记形成对比，支持人类起源于非洲的假设。
GENETIC variation at hypervariable loci is being used extensively for linkage analysis1 and individual identification2, and may be useful for inter-population studies2-5. Here we show that polymorphic microsatellites (primarily CA repeats) allow trees of human individuals to be constructed that reflect their geographic origin with remarkable accuracy. This is achieved by the analysis of a large number of loci for each individual, in spite of the small variations in allele frequencies existing between populations6,7. Reliable evolutionary relationships could also be established in comparisons among human populations but not among great ape species, probably because of constraints on allele length variation. Among human populations, diversity of microsatellites is highest in Africa, which is in contrast to other nuclear markers and supports the hypothesis of an African origin for humans.