Predicting Cardiovascular Stent Complications Using Self-Reporting Biosensors for Noninvasive Detection of Disease.
Predicting Cardiovascular Stent Complications Using Self-Reporting Biosensors for Noninvasive Detection of Disease.
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DOI：
10.1002/advs.202105285
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发表时间：
2022-05
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自我报告的植入式医疗设备是心血管保健的未来。心血管并发症，如导致大多数心脏病发作和中风的动脉阻塞，通常用惰性金属支架治疗，使受影响的血管重新开放。由于支架内再狭窄（ISR）的伤口反应，支架部署后经常会再次阻塞。本文开发了一种可植入的微型传感器和遥测系统，可以检测这一过程，识别与ISR相关的不同细胞类型，区分亚斑块成分，如离体样品所示，并区分血液和血凝块，所有这些都在硅衬底上，使其适合集成到血管支架上。这项工作表明，与之前的培养细胞工作相比，微制造传感器可以在更接近生理条件的环境中提供临床相关信息。一种可植入的微型传感器和遥测系统可以检测和识别与支架内再狭窄相关的不同细胞类型，区分亚斑块成分，并区分血液和血凝块。这项工作表明，与之前的培养细胞工作相比，微制造传感器可以在更接近生理条件的环境中提供临床相关信息。
Self‐reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re‐block after deployment due to a wound response called in‐stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells. An implantable miniaturized sensor and telemetry system is developed that can detect and discern different cell types associated with in stent restenosis, distinguish sub plaque components, and differentiate blood from blood clot. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.